ArticleJournal of the American Chemical Society2008
Characterization of CalE10, the N-oxidase involved in calicheamicin hydroxyaminosugar formation.
Article in Journal of the American Chemical Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Direct aromatic nitration by bacterial P450 enzymes.Methods in enzymology · 2023Article
- Characterization of the flavoenzyme XiaK as anChemical science · 2017Article
- Heteroatom-Heteroatom Bond Formation in Natural Product Biosynthesis.Chemical reviews · 2017Review
- Structural dynamics of a methionine γ-lyase for calicheamicin biosynthesis: Rotation of the conserved tyrosine stacking with pyridoxal phosphate.Structural dynamics (Melville, N.Y.) · 2016Article
- Structure-guided functional characterization of enediyne self-sacrifice resistance proteins, CalU16 and CalU19.ACS chemical biology · 2014Article
- A general NMR-based strategy for the in situ characterization of sugar-nucleotide-dependent biosynthetic pathways.Organic letters · 2014Article
- The biosynthesis of nitrogen-, sulfur-, and high-carbon chain-containing sugars.Chemical Society reviews · 2013Review
- The structural biology of enzymes involved in natural product glycosylation.Natural product reports · 2012Review
- Mechanisms and structures of vitamin B(6)-dependent enzymes involved in deoxy sugar biosynthesis.Biochimica et biophysica acta · 2011Review
- Glycosyloxyamine neoglycosylation: a model study using calicheamicin.ChemMedChem · 2011Article
- Structure and mechanism of ORF36, an amino sugar oxidizing enzyme in everninomicin biosynthesis .Biochemistry · 2010Article
- Metalloenzymes: Natural product nitrosation.Nature chemical biology · 2010Article
- Use of N-methylformamide as a solvent in indium-promoted Barbier reactions en route to enediyne and epoxy diyne formation: comparison of rate and stereoselectivity in C-C bond-forming reactions with water.The Journal of organic chemistry · 2009Article
- Increasing carbohydrate diversity via amine oxidation: aminosugar, hydroxyaminosugar, nitrososugar, and nitrosugar biosynthesis in bacteria.Current opinion in chemical biology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
As the first in vitro characterization of a sugar N-oxidase, this study establishes CalE10 as the key oxidase involved in calicheamicin hydroxylamino glycoside formation. This study confirms that oxidation occurs at the sugar nucleotide stage prior to glycosyltransfer, and substrate specificity studies reveal CalE10-catalyzed oxidation to be regiospecific and to present trace amounts of the corresponding nitrosugar in vitro. This work also sets a precedent for the future study of other N-oxidases involved in hydroxylamino-, nitroso-, and/or nitrosugar formation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.