ArticleBlood cells, molecules & diseases
Fibrin architecture in clots: a quantitative polarized light microscopy analysis.
Article in Blood cells, molecules & diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 54 citations in OpenAlex.
- Fibrin as a Versatile Fibrous Biopolymer.Sub-cellular biochemistry · 2026Review
- "What makes blood clots break off?" A Back-of-the-Envelope Computation Toward Explaining Clot Embolization.Cardiovascular engineering and technology · 2024Article
- Multiscale mechanical characterization and computational modeling of fibrin gels.Acta biomaterialia · 2023Article
- Instant polarized light microscopy pi (IPOLπ) for quantitative imaging of collagen architecture and dynamics in ocular tissues.bioRxiv : the preprint server for biology · 2023Article
- Development of a mesoscopic framework spanning nanoscale protofibril dynamics to macro-scale fibrin clot formation.Journal of the Royal Society, Interface · 2021Article
- Role of Shear Stress and tPA Concentration in the Fibrinolytic Potential of Thrombi.International journal of molecular sciences · 2021Article
- The distinctive structure and composition of arterial and venous thrombi and pulmonary emboli.Scientific reports · 2020Article
- Fibrin Formation, Structure and Properties.Sub-cellular biochemistry · 2017Review
- Computational imaging analysis of fibrin matrices with the inclusion of erythrocytes from homozygous SS blood reveals agglomerated and amorphous structures.Journal of thrombosis and thrombolysis · 2017Article
- Biophysical Mechanisms Mediating Fibrin Fiber Lysis.BioMed research international · 2017Review
- Fibrin Networks Support Recurring Mechanical Loads by Adapting their Structure across Multiple Scales.Biophysical journal · 2016Article
- Mechanical Stimulation Increases Knee Meniscus Gene RNA-level Expression in Adipose-derived Stromal Cells.Plastic and reconstructive surgery. Global open · 2016Article
- Efficacy of histotripsy combined with rt-PA in vitro.Physics in medicine and biology · 2016Article
- Molecular Mechanism Responsible for Fibronectin-controlled Alterations in Matrix Stiffness in Advanced Chronic Liver Fibrogenesis.The Journal of biological chemistry · 2016Article
- A Computational Model of Biochemomechanical Effects of Intraluminal Thrombus on the Enlargement of Abdominal Aortic Aneurysms.Annals of biomedical engineering · 2015Article
- Effects of unidirectional flow shear stresses on the formation, fractal microstructure and rigidity of incipient whole blood clots and fibrin gels.Clinical hemorheology and microcirculation · 2015Article
- Review
- Biochemomechanics of intraluminal thrombus in abdominal aortic aneurysms.Journal of biomechanical engineering · 2013Review
- Strain tunes proteolytic degradation and diffusive transport in fibrin networks.Biomacromolecules · 2012Article
- Mechanical behavior of collagen-fibrin co-gels reflects transition from series to parallel interactions with increasing collagen content.Journal of biomechanical engineering · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Fibrin plays a vital structural role in thrombus integrity. Thus, the ability to assess fibrin architecture has a potential to provide insight into thrombosis and thrombolysis. Fibrin has an anisotropic molecular structure, which enables it to be seen with polarized light. Therefore, we aimed to determine if automated polarized light microscopy methods of quantifying two structural parameters; fibrin fiber bundle orientation and fibrin's optical retardation (OR: a measure of molecular anisotropy) could be used to assess thrombi. To compare fibrin fiber bundle orientation we analyzed picrosirius red-stained sections obtained from clots formed: (A) in vitro, (B) in injured and stenotic coronary arteries, and (C) in surgically created aortic aneurysms (n=6 for each group). To assess potential changes in OR, we examined fibrin in picrosirius red-stained clots formed after ischemic preconditioning (10 min ischemia+10 min reflow; a circumstance shown to enhance lysability) and in control clots (n=8 each group). The degree of fibrin organization differed significantly according to the location of clot formation; fibrin was most aligned in the aneurysms and least aligned in vitro whereas fibrin in the coronary clots had an intermediate organization. The OR of fibrin in the clots formed after ischemic preconditioning was lower than that in controls (2.9+/-0.5 nm versus 5.4+/-1.0 nm, P<0.05). The automated polarized light analysis methods not only enabled fibrin architecture to be assessed, but also revealed structural differences in clots formed under different circumstances.
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