ArticleMolecular microbiology2009
Multiple roles of Pseudomonas aeruginosa TBCF10839 PilY1 in motility, transport and infection.
Article in Molecular microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 57 citations in OpenAlex.
- PilY proteins: bimodular drivers of type IV pilus versatility.Trends in microbiology · 2026Review
- Defining the role ofJournal of bacteriology · 2026Article
- A prophage-expressed type IV pilus component provides anti-phage defense.Cell reports · 2026Article
- Diversity, classification, and evolution of myxobacterial PilY1 proteins.Frontiers in microbiology · 2026Article
- Separation ofmBio · 2025Article
- Versatile roles of rubredoxin reductase of Pseudomonas aeruginosa TBCF10839 in virulence and stress protection.PLoS pathogens · 2025Article
- PilY1 regulates the dynamic architecture of the type IV pilus machine in Pseudomonas aeruginosa.Nature communications · 2024Article
- A VirB4 ATPase of the mobile accessory genome orchestrates core genome-encoded features of physiology, metabolism, and virulence ofFrontiers in cellular and infection microbiology · 2023Article
- Transcriptional profiling of biofilms formed on chilled beef by psychrotrophic meat spoilage bacterium,Biofilm · 2021Article
- Insight Into the Virulence Related Secretion Systems, Fimbriae, and Toxins in O2:K1Frontiers in veterinary science · 2021Article
- Cytotoxic alkyl-quinolones mediate surface-induced virulence in Pseudomonas aeruginosa.PLoS pathogens · 2020Article
- Phenazines as potential biomarkers of Pseudomonas aeruginosa infections: synthesis regulation, pathogenesis and analytical methods for their detection.Analytical and bioanalytical chemistry · 2020Review
- The RpoN2-PilRX regulatory system governs type IV pilus gene transcription and is required for bacterial motility and virulence in Xanthomonas oryzae pv. oryzae.Molecular plant pathology · 2020Article
- A Shift in Central Metabolism Accompanies Virulence Activation in Pseudomonas aeruginosa.mBio · 2020Article
- Pseudomonas aeruginosa type IV minor pilins and PilY1 regulate virulence by modulating FimS-AlgR activity.PLoS pathogens · 2018Article
- Different Dose-Dependent Modes of Action of C-Type Natriuretic Peptide onPathogens (Basel, Switzerland) · 2018Article
- Construction, expression, purification and characterization of secretin domain of PilQ and triple PilA-related disulfide loop peptides fusion protein fromIranian journal of basic medical sciences · 2017Article
- PilY1 PromotesFrontiers in cellular and infection microbiology · 2017Article
- Article
- Development of a Novel Anti-Adhesive Vaccine AgainstInternational journal of molecular and cellular medicine · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polymorphonuclear neutrophils are the most important mammalian host defence cells against infections with Pseudomonas aeruginosa. Screening of a signature tagged mutagenesis library of the non-piliated P. aeruginosa strain TBCF10839 uncovered that transposon inactivation of its pilY1 gene rendered the bacterium more resistant against killing by neutrophils than the wild type and any other of the more than 3000 tested mutants. Inactivation of pilY1 led to the loss of twitching motility in twitching-proficient wild-type PA14 and PAO1 strains, predisposed to autolysis and impaired the secretion of quinolones and pyocyanin, but on the other hand promoted growth in stationary phase and bacterial survival in murine airway infection models. The PilY1 population consisted of a major full-length and a minor shorter PilY1* isoform. PilY1* was detectable in small extracellular quinolone-positive aggregates, but not in the pilus. P. aeruginosa PilY1 is not an adhesin on the pilus tip, but assists in pilus biogenesis, twitching motility, secretion of secondary metabolites and in the control of cell density in the bacterial population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.