ArticleNucleic acids research1991
The genomic organization of immunoglobulin VH genes in Xenopus laevis shows evidence for interspersion of families.
Article in Nucleic acids research, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Identification and characterization of T-cell antigen receptor-related genes in phylogenetically diverse vertebrate species.Immunogenetics · 1995Article
- VH gene organization in a relict species, the coelacanth Latimeria chalumnae: evolutionary implications.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- What limits affinity maturation of antibodies in Xenopus--the rate of somatic mutation or the ability to select mutants?The EMBO journal · 1992Article
- A deletion polymorphism in the human alpha-2-macroglobulin (A2M) gene.Nucleic acids research · 1991Article
- New nucleotide sequence data on the EMBL File Server.Nucleic acids research · 1991Article
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Authors and funding
5 authors.
Funding
Abstract
The complete genomic sequences of Xenopus laevis immunoglobulin heavy chain variable region (VH) genes comprising families IV-XI are reported. Using VH family-specific probes, linkage relationships for Xenopus VHI-VHXI have been determined. With the possible exceptions of VHIII and VHVII, Xenopus VH genes appear to be interspersed. When from two to five VH segments are identified in individual clones, the elements are found to be in the same relative transcriptional orientation. Although the relationships of promoter sequences, including the regulatory octamer, resemble those seen in other vertebrate VH genes, several Xenopus VH families are associated with additional 5' octamer sequences and octamer-like motifs. The similarities between the genomic organization of VH genes in Xenopus and higher vertebrates, indicate an early phylogenetic emergence of the mammalian-type of gene organization and regulation.
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