ArticleLangmuir : the ACS journal of surfaces and colloids2008
Scanning electrochemical microscopy of DNA monolayers modified with Nile Blue.
Article in Langmuir : the ACS journal of surfaces and colloids, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Permeability-Based Measurement of Nanobody Binding to Nuclear Pore Complexes by Transient Scanning Electrochemical Microscopy.Analytical chemistry · 2026Article
- Energy-Biosensor Synergy: Intrinsic Catalytic Reactions as Label-Free Signal Pathways.Sensors (Basel, Switzerland) · 2026Review
- Normalized Multipotential Redox Coding of DNA Bases for Determination of Total Nucleotide Composition.Analytical chemistry · 2023Article
- DNA Electrochemistry: Charge-Transport Pathways through DNA Films on Gold.Journal of the American Chemical Society · 2021Article
- Biological imaging with scanning electrochemical microscopy.Proceedings. Mathematical, physical, and engineering sciences · 2018Review
- Helix-Dependent Spin Filtering through the DNA Duplex.Journal of the American Chemical Society · 2016Article
- Survey of Redox-Active Moieties for Application in Multiplexed Electrochemical Biosensors.Analytical chemistry · 2016Article
- Electrocatalysis in DNA Sensors.Polyhedron · 2014Article
- DNA-modified electrodes fabricated using copper-free click chemistry for enhanced protein detection.Langmuir : the ACS journal of surfaces and colloids · 2013Article
- Electrochemical patterning and detection of DNA arrays on a two-electrode platform.Journal of the American Chemical Society · 2013Article
- DNA sensing by electrocatalysis with hemoglobin.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
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5 authors.
Funding
Abstract
Scanning electrochemical microscopy (SECM) is used to probe long-range charge transport (CT) through DNA monolayers containing the redox-active Nile Blue (NB) intercalator covalently affixed at a specific location in the DNA film. At substrate potentials negative of the formal potential of covalently attached NB, the electrocatalytic reduction of Fe(CN)6(3-) generated at the SECM tip is observed only when NB is located at the DNA/solution interface; for DNA films containing NB in close proximity to the DNA/electrode interface, the electrocatalytic effect is absent. This behavior is consistent with both rapid DNA-mediated CT between the NB intercalator and the gold electrode as well as a rate-limiting electron transfer between NB and the solution phase Fe(CN)6(3-). The DNA-mediated nature of the catalytic cycle is confirmed through sequence-specific and localized detection of attomoles of TATA-binding protein, a transcription factor that severely distorts DNA upon binding. Importantly, the strategy outlined here is general and allows for the local investigation of the surface characteristics of DNA monolayers both in the absence and in the presence of DNA binding proteins. These experiments highlight the utility of DNA-modified electrodes as versatile platforms for SECM detection schemes that take advantage of CT mediated by the DNA base pair stack.
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