ReviewBioconjugate chemistry2009
Bioconjugate-based molecular umbrellas.
Review in Bioconjugate chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 64 citations in OpenAlex.
- Medical and Nonmedical Applications of Synthetic Transmembrane Anion Transporters.Chemical reviews · 2025Review
- Quasi-Podands with 1,2,3-Triazole Rings from Bile Acid Derivatives: Synthesis, and Spectroscopic and Theoretical Studies.The Journal of organic chemistry · 2024Article
- Mechanistic Understanding from Molecular Dynamics in Pharmaceutical Research 2: Lipid Membrane in Drug Design.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Molecular Umbrella as a Nanocarrier for Antifungals.Molecules (Basel, Switzerland) · 2021Article
- Mechanistic Understanding From Molecular Dynamics Simulation in Pharmaceutical Research 1: Drug Delivery.Frontiers in molecular biosciences · 2020Review
- Taming Amphotericin B.Bioconjugate chemistry · 2015Article
- Cholate-based synthesis of size-tunable cage compounds.The Journal of organic chemistry · 2015Article
- Molecular umbrella-amphotericin B conjugates.Bioconjugate chemistry · 2014Article
- Synthesis, spectroscopic and theoretical studies of new quasi-podands from bile acid derivatives linked by 1,2,3-triazole rings.Molecules (Basel, Switzerland) · 2014Article
- Molecular umbrella conjugate for the ocular delivery of siRNA.Bioconjugate chemistry · 2014Article
- The core-inversible micelles for hydrophilic drug delivery.Chemical communications (Cambridge, England) · 2013Article
- A molecular umbrella approach to the intracellular delivery of small interfering RNA.Bioconjugate chemistry · 2011Article
- Well-defined, size-tunable, multifunctional micelles for efficient paclitaxel delivery for cancer treatment.Bioconjugate chemistry · 2010Article
- A novel size-tunable nanocarrier system for targeted anticancer drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2010Article
- A fine line between molecular umbrella transport and ionophoric activity.Bioconjugate chemistry · 2009Article
- Disterolphospholipids: nonexchangeable lipids and their application to liposomal drug delivery.Angewandte Chemie (International ed. in English) · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Molecular umbrellas are "amphomorphic" compounds that can produce a hydrophobic or hydrophilic exterior when exposed to a hydrophobic or hydrophilic microenvironment, respectively. Such molecules are composed of two or more facial amphiphiles that are connected to a central scaffold. Molecular umbrellas that have been synthesized to date, using bile acids as umbrella "walls", polyamines such as spermidine and spermine as scaffold material, and l-lysine as "branches", have been found capable of transporting certain hydrophilic peptides, nucleotides, and oligonucleotides across liposomal membranes by passive diffusion. They have also have been shown to increase water solubility and hydrolytic stability of a hydrophobic drug, and to exhibit significant antiviral activity. The ability of a fluorescently labeled molecular umbrella to readily enter live HeLa cells suggests that such conjugates could find use as drug carriers.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.