Evidence map›Paper›PMID 19053187›Full record

ArticleJournal of the American Chemical Society2008

Surface-enhanced Raman scattering tags for rapid and homogeneous detection of circulating tumor cells in the presence of human whole blood.

Michael Y Sha, Hongxia Xu, Michael J Natan, Remy Cromer

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed.

  1. A Raman-based endoscopic strategy for multiplexed molecular imaging.Proceedings of the National Academy of Sciences of the United States of America · 2013
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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michael Y ShaOxonica Inc., 325 East Middlefield Road, Mountain View, California 94043, USA. mike_sha168@yahoo.com
Hongxia Xu
Michael J Natan
Remy Cromer

Funding

Tissue and Animal UseU54CA119338 · NCI · EMORY UNIVERSITY · PI NIE, SHUMING · 2005 to 2009
$18.4M
NCI NIH HHS U54 CA119338NCI NIH HHS U54CA119338-01PHS HHS 5-40255-G6
6 · The paper itself

Abstract

A novel, homogeneous SERS-based cell detection assay was developed for rapid and direct enumeration of circulating tumor cells in the presence of whole blood. Magnetic beads and SERS tags were respectively conjugated to EpCAM and her2 antibodies for the capture and detection of approximately 50 tumor cells/mL in the presence of whole blood in less than 1 h.

Indexed as

Antigens, NeoplasmApoptosisBloodCell Adhesion MoleculesCell LineDose-Response Relationship, DrugEpithelial Cell Adhesion MoleculeHumansMagneticsMicroscopy, Electron, TransmissionModels, BiologicalNeoplastic Cells, CirculatingScattering, RadiationSignal TransductionSpectrum Analysis, RamanSurface PropertiesAntigens, NeoplasmCell Adhesion MoleculesEpithelial Cell Adhesion Molecule

Identifiers

PMID19053187
PMCPMC2648857

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.