ArticleMovement disorders : official journal of the Movement Disorder Society2009
Movement disturbances in the differential diagnosis of Creutzfeldt-Jakob disease.
Article in Movement disorders : official journal of the Movement Disorder Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Palliative care symptoms of people living with rapidly progressive prion diseases: a systematic review.BMC palliative care · 2026Pooled it
- Supranuclear Vertical Gaze Palsy in Movement Disorders.Neuro-ophthalmology (Aeolus Press) · 2025Review
- Improving Early Recognition of Treatment-Responsive Causes of Rapidly Progressive Dementia: The STAMAnnals of neurology · 2024Observational
- Progressive supranuclear palsy phenotype as an atypical clinical presentation of Creutzfeldt-Jakob disease: A case report and review of the literature.Clinical parkinsonism & related disorders · 2024Article
- Spectrum and Pattern of Movement Disorders in Patients with Sporadic Creutzfeldt-Jakob Disease.Tremor and other hyperkinetic movements (New York, N.Y.) · 2023Article
- Prevalence and Treatments of Movement Disorders in Prion Diseases: A Longitudinal Cohort Study.Movement disorders : official journal of the Movement Disorder Society · 2022Article
- Combining Literature Review With a Ground Truth Approach for Diagnosing Huntington's Disease Phenocopy.Frontiers in neurology · 2022Article
- Hypertrophic Olivary Degeneration and Movement Disorder in a Patient with Familial Creutzfeldt-Jakob Disease.Cureus · 2020Article
- Chorea in Sporadic Creutzfeldt-Jakob Disease.Journal of movement disorders · 2018Article
- Sporadic MM-1 Type Creutzfeldt-Jakob Disease With Hemiballic Presentation and No Cognitive Impairment Until Death: How New NCJDRSU Diagnostic Criteria May Allow Early Diagnosis.Frontiers in neurology · 2018Article
- Stereotypic Movements in Case of Sporadic Creutzfeldt-Jakob Disease: Possible Role of Anti-NMDA Receptor Antibodies.Case reports in neurology · 2012Article
- Movement disorders reveal Creutzfeldt-Jakob disease.Nature reviews. Neurology · 2009Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Movement disturbances are common in dementia disorders and are a central feature of the clinical classification criteria of Creutzfeldt-Jakob disease (CJD). Polymorphism at codon 129 of the prion protein gene is known to determine the clinical picture of CJD. The frequency and characteristics of movement disturbances in other dementing disorders, such as Alzheimer's disease (AD), is barely known and leads to misdiagnoses. We investigated the occurrence and characteristics of movement disturbances in 143 patients neuropathologically confirmed with CJD (n = 100), AD (n = 29), dementia with Lewy bodies (DLB) (n = 7), or other diagnoses (n = 7). All patients had been referred with the differential diagnosis of prion disease. Ataxia and dysmetria were significantly more frequent in CJD than in AD or DLB patients, whereas hypokinesia was up to five times more frequent in AD or DLB (P < 0.05). Using an ordered logistic regression to identify constellations of movement disturbances, the diagnosis of CJD was likely in patients presenting ataxia but not hypokinesia. The reverse situation was statistically associated with AD. Ataxia and cogwheel rigidity were associated with valine-homozygosity and akinesia with methionine-homozygosity in the CJD patients. Our results indicate that the careful assessment of movement disturbances may be helpful in the differential diagnosis of Creutzfeldt-Jakob disease.
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