ArticleJournal of molecular modeling2009
Docking studies suggest ligand-specific delta-opioid receptor conformations.
Article in Journal of molecular modeling, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 5 citations in OpenAlex.
- Interaction and regulatory functions of μ- and δ-opioid receptors in nociceptive afferent neurons.Neuroscience bulletin · 2012Review
- Coexpression of delta- and mu-opioid receptors in nociceptive sensory neurons.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
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Abstract
An automated docking procedure was used to study binding of a series of delta-selective ligands to three models of the delta-opioid receptor. These models are thought to represent the three ligand-specific receptor conformations. Docking results are in agreement with point mutation studies and suggest that different ligands--agonists and antagonists--may bind to the same binding site under different receptor conformations. Docking to different receptor models (conformations) also suggests that by changing to a receptor-specific conformation, the receptor may open or close different binding sites to other ligands.
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