ReviewDie Naturwissenschaften2009
Remodeling the clock: coactivators and signal transduction in the circadian clockworks.
Review in Die Naturwissenschaften, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Clock-linked genes underlie seasonal migratory timing in a diurnal raptor.Proceedings. Biological sciences · 2022Article
- Circadian Phenotype Composition is a Major Predictor of Diurnal Physical Performance in Teams.Frontiers in neurology · 2015Article
- Form and function remixed: developmental physiology in the evolution of vertebrate body plans.The Journal of physiology · 2014Review
- Circadian rhythms and period expression in the Hawaiian cricket genus Laupala.Behavior genetics · 2013Article
- The E3 ubiquitin ligase CTRIP controls CLOCK levels and PERIOD oscillations in Drosophila.EMBO reports · 2011Article
- A comparative view of insect circadian clock systems.Cellular and molecular life sciences : CMLS · 2010Review
- Diabetic retinopathy is associated with bone marrow neuropathy and a depressed peripheral clock.The Journal of experimental medicine · 2009Article
- Sequential and compartment-specific phosphorylation controls the life cycle of the circadian CLOCK protein.The Journal of biological chemistry · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most organisms on earth such as cyanobacteria, fungi, plants, insects, animals, and humans synchronize their physiological and behavioral activities with the environmental cycles of day and night. Significant progress has been made in unraveling the genetic components that constitute a molecular circadian clock, which facilitates the temporal control of physiology and behavior. Clock genes assemble interlocked transcriptional/translational feedback loops that underlie the circadian oscillations. Recent investigations revealed that posttranslational regulation of clock proteins is crucial for functioning of the molecular oscillator and for precise temporal control of circadian transcription. This review provides an overview of the homologous clockworks in Drosophila and mammals, with a special focus on recent insights in the posttranslational regulation of clock proteins as well as the role of coactivators, repressors, and signal transduction for circadian controlled genome-wide transcription. The emerging mechanisms of clock gene regulation provide an understanding of the temporal control of transcription in general and the circadian orchestration of physiology and behavior in particular.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.