ArticleJournal of perinatology : official journal of the California Perinatal Association2009
Acute hemodynamic effects of caffeine administration in premature infants.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03086473 (A Randomized, Placebo-controlled Trial of Early Caffeine in Preterm Neonates), which is not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized, Placebo-controlled Trial of Early Caffeine in Preterm Neonates
Who cites it
18 citing papers in PubMed, 54 citations in OpenAlex.
- A pilot randomized trial of high-dose caffeine therapy in preterm infants.Pediatric research · 2015Trial
- High versus low-dose caffeine for apnea of prematurity: a randomized controlled trial.European journal of pediatrics · 2015Trial
- Cardiovascular and cerebrovascular effects of caffeine maintenance in preterm infants during the transitional period.Pediatric research · 2024Observational
- Caffeine pharmacokinetics following umbilical vein injection during delayed cord clamping in preterm lambs.Pediatric research · 2024Article
- Precision caffeine therapy for apnea of prematurity and circadian rhythms: New possibilities open up.Frontiers in pharmacology · 2022Review
- Caffeine: cardiorespiratory effects and tissue protection in animal models.Experimental animals · 2021Review
- Optimizing respiratory management in preterm infants: a review of adjuvant pharmacotherapies.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- Caffeine in preterm infants: where are we in 2020?ERJ open research · 2020Review
- Non-invasive Cardiac Output Monitoring in Neonates.Frontiers in pediatrics · 2020Review
- Dosing and Safety of Off-label Use of Caffeine Citrate in Premature Infants.The Journal of pediatrics · 2019Article
- [Clinical effect of early or late administration of caffeine citrate in prevention and treatment of apnea in very low birth weight infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2018Article
- Hemodynamic Effects on Systemic Blood Flow and Ductal Shunting Flow after Loading Dose of Intravenous Caffeine in Preterm Infants according to the Patency of Ductus Arteriosus.Journal of Korean medical science · 2018Article
- Haemodynamic effects of prenatal caffeine on the cardiovascular transition in ventilated preterm lambs.PloS one · 2018Article
- Article
- Caffeine therapy in preterm infants.World journal of clinical pediatrics · 2015Review
- Trends in caffeine use and association between clinical outcomes and timing of therapy in very low birth weight infants.The Journal of pediatrics · 2014Article
- Early caffeine therapy and clinical outcomes in extremely preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2013Article
- Evaluation of Timing and Dosing of Caffeine Citrate in Preterm Neonates for the Prevention of Bronchopulmonary Dysplasia.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAGArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAdministration of caffeine citrate (caffeine) has been a central component of the treatment of apnea of prematurity. However, given its multiple pharmacologic effects, caffeine might be expected to produce hemodynamic changes in heart rate, stroke volume, cardiac output and vascular resistance. STUDY
designIn this prospective observational study, we report the hemodynamic effects of intravenous caffeine administration in a population of premature infants who received caffeine to correct or prevent apnea of prematurity.
methodsHemodynamic effects of caffeine were determined in 31 infants. Stroke volume was measured via echocardiogram, using velocity time integral at the aortic root diameter. Statistically univariate analyses were performed parametrically using paired t-test and nonparametrically (sign test). Multivariate linear regression models were used to identify subgroup covariate effects.
resultsAfter intravenous caffeine, cardiac index increased in 31 of 31 trials, by an average of 14.6+/-16.3% (s.d.); stroke volume increased in 24 of 31 trials, by 7.8+/-12.2%; heart rate increased in 28 of 31 trials by 7.7+/-7.2 beats per min; and blood pressure increased in 25 of 31 trials, by 4.1+/-5.8 mm Hg (all P<0.001). Multivariate linear regression revealed no significant effect of dose, birth weight, gestational age or postnatal age.
conclusionsIntravenous caffeine consistently increases cardiac output and blood pressure in relatively stable premature infants, when given to treat or prevent apnea of prematurity. We speculate that there may be a role for caffeine in the hemodynamic treatment of hypotensive/hypoperfused infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.