ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Tuning thalamic firing modes via simultaneous modulation of T- and L-type Ca2+ channels controls pain sensory gating in the thalamus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed, 62 citations in OpenAlex.
- Review
- Deletion of Phospholipase C β1 in the Thalamic Reticular Nucleus Induces Absence Seizures.Experimental neurobiology · 2022Article
- L-cysteine modulates visceral nociception mediated by the CaPflugers Archiv : European journal of physiology · 2022Article
- Neural Burst Firing and Its Roles in Mental and Neurological Disorders.Frontiers in cellular neuroscience · 2021Article
- Excitatory Repetitive Transcranial Magnetic Stimulation Over Prefrontal Cortex in a Guinea Pig Model Ameliorates Tinnitus.Frontiers in neuroscience · 2021Article
- Destabilization of light NREM sleep by thalamic PLCβ4 deletion impairs sleep-dependent memory consolidation.Scientific reports · 2020Article
- Realising the therapeutic potential of neuroactive steroid modulators of the GABANeurobiology of stress · 2020Article
- A Computational Modeling Reveals That Strength of Inhibitory Input, E/I Balance, and Distance of Excitatory Input Modulate Thalamocortical Bursting Properties.Experimental neurobiology · 2019Article
- Distinct Topographical Patterns of Spike-Wave Discharge in Transgenic and Pharmacologically Induced Absence Seizure Models.Experimental neurobiology · 2019Article
- Article
- Yin-and-yang bifurcation of opioidergic circuits for descending analgesia at the midbrain of the mouse.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Auditory thalamic circuits and GABAHearing research · 2017Review
- Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior.Scientific reports · 2017Article
- Reduced GABAergic transmission in the ventrobasal thalamus contributes to thermal hyperalgesia in chronic inflammatory pain.Scientific reports · 2017Article
- Reduced GABAergic neuronal activity in zona incerta causes neuropathic pain in a rat sciatic nerve chronic constriction injury model.Journal of pain research · 2017Article
- The thalamic mGluR1-PLCβ4 pathway is critical in sleep architecture.Molecular brain · 2016Article
- The CaNature communications · 2016Article
- Medial septal GABAergic projection neurons promote object exploration behavior and type 2 theta rhythm.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Thalamic Bursts and the Epic Pain Model.Frontiers in computational neuroscience · 2016Article
- Function of mGlu1 receptors in the modulation of nociceptive processing in the thalamus.Neuropharmacology · 2014Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two firing modes of thalamocortical (TC) neurons, tonic and burst firings, are thought to reflect the divergent states of sensory signal transmission from the thalamus to the cortex. However, the behavioral consequences of changes in the thalamic firing between the two modes have not been well demonstrated. Moreover, although the firing modes of TC neurons are known to be affected by corticothalamic inputs via thalamic metabotropic glutamate receptor type 1 (mGluR1)-phospholipase C beta4 (PLCbeta4) pathway, its molecular mechanisms have not been well elucidated. We addressed these questions using PLCbeta4-deficient mice, which show decreased visceral pain responses. We demonstrate that burst and tonic firings of TC neurons are concomitantly regulated by PLCbeta4 pathway. Blocking of this pathway by the mutation simultaneously increases bursting and decreases tonic firing of TC neurons through concurrent upregulation of T- and L-type Ca(2+) currents. The mice with increased bursting and decreased tonic firing of TC neurons showed reduced visceral pain responses. Furthermore, we show that modulation of the Ca(2+) channels or protein kinase C (PKC), a downstream molecule of PLCbeta4, altered the firing modes of TC neurons and pain responses in the predicted ways. Our data demonstrate the molecular mechanism and behavioral consequences of altered firing modes of TC neurons in relaying the visceral pain signals. Our study also highlights the thalamic PLCbeta4-PKC pathway as a "molecular switch" for the firing modes of TC neurons and thus for pain sensory gating.
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