ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Fgf-2 overexpression increases excitability and seizure susceptibility but decreases seizure-induced cell loss.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Olfactory Mucosa MSCs-Derived Exosomal RPL6 Attenuates Seizure-Induced Neuronal Damage via FGF2-Mediated Oxidative Stress and Mitophagy.Neurochemical research · 2026Article
- FGF family in health and disease.Molecular biomedicine · 2026Review
- Environmental enrichment and physical exercise prevent stress-induced social avoidance and blood-brain barrier alterations via Fgf2.Nature communications · 2026Article
- The Dual Role of Extracellular Vesicles in Aging and Age-Related Diseases: Pathophysiology and Therapeutic Potential.International journal of nanomedicine · 2026Review
- Fibroblast growth factor signaling in axons: from development to disease.Cell communication and signaling : CCS · 2023Review
- Soluble tumor necrosis factor-alpha-induced hyperexcitability contributes to retinal ganglion cell apoptosis by enhancing Nav1.6 in experimental glaucoma.Journal of neuroinflammation · 2021Article
- Astrocyte-derived extracellular vesicles: Neuroreparative properties and role in the pathogenesis of neurodegenerative disorders.Journal of controlled release : official journal of the Controlled Release Society · 2020Review
- Blood-brain barrier disruption and angiogenesis in a rat model for neurocysticercosis.Journal of neuroscience research · 2019Article
- FGF binding proteins (FGFBPs): Modulators of FGF signaling in the developing, adult, and stressed nervous system.Biochimica et biophysica acta. Molecular basis of disease · 2018Review
- CNTF-Treated Astrocyte Conditioned Medium Enhances Large-Conductance Calcium-Activated Potassium Channel Activity in Rat Cortical Neurons.Neurochemical research · 2016Article
- Deletion of fibroblast growth factor 22 (FGF22) causes a depression-like phenotype in adult mice.Behavioural brain research · 2016Article
- The Contradictory Effects of Neuronal Hyperexcitation on Adult Hippocampal Neurogenesis.Frontiers in neuroscience · 2016Review
- FGF Signaling Is Necessary for Neurogenesis in Young Mice and Sufficient to Reverse Its Decline in Old Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Implication of fibroblast growth factors in epileptogenesis-associated circuit rearrangements.Frontiers in cellular neuroscience · 2013Article
- Neuroprotective and antiepileptogenic effects of combination of anti-inflammatory drugs in the immature brain.Journal of neuroinflammation · 2013Article
- Suppression of epileptogenesis-associated changes in response to seizures in FGF22-deficient mice.Frontiers in cellular neuroscience · 2013Article
- Transcriptomic profiling of human peritumoral neocortex tissues revealed genes possibly involved in tumor-induced epilepsy.PloS one · 2013Article
- FGF ligands emerge as potential specifiers of synaptic identity.Cellscience · 2010Article
- Transient protective effect of B-vitamins in experimental epilepsy in the mouse brain.Journal of molecular neuroscience : MN · 2010Article
- Enhancement of GABA(A)-current run-down in the hippocampus occurs at the first spontaneous seizure in a model of temporal lobe epilepsy.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fibroblast growth factor 2 (FGF-2) has multiple, pleiotropic effects on the nervous system that include neurogenesis, neuroprotection and neuroplasticity. Thus, alteration in FGF-2 expression patterns may have a profound impact in brain function, both in normal physiology and in pathology. Here, we used FGF-2 transgenic mice (TgFGF2) to study the effects of endogenous FGF-2 overexpression on susceptibility to seizures and to the pathological consequences of seizures. TgFGF2 mice display increased FGF-2 expression in hippocampal pyramidal neurons and dentate granule cells. Increased density of glutamatergic synaptic vesicles was observed in the hippocampus of TgFGF2 mice, and electrophysiological data (input/output curves and patch-clamp recordings in CA1) confirmed an increase in excitatory inputs in CA1, suggesting the presence of a latent hyperexcitability. Indeed, TgFGF2 mice displayed increased susceptibility to kainate-induced seizures compared with wild-type (WT) littermates, in that latency to generalized seizure onset was reduced, whereas behavioral seizure scores and lethality were increased. Finally, WT and TgFGF2 mice with similar seizure scores were used for examining seizure-induced cellular consequences. Neurogenesis and mossy fiber sprouting were not significantly different between the two groups. In contrast, cell damage (assessed with Fluoro-Jade B, silver impregnation and anti-caspase 3 immunohistochemistry) was significantly lower in TgFGF2 mice, especially in the areas of overexpression (CA1 and CA3), indicating reduction of seizure-induced necrosis and apoptosis. These data suggest that FGF-2 may be implicated in seizure susceptibility and in seizure-induced plasticity, exerting different, and apparently contrasting effects: favoring ictogenesis but reducing seizure-induced cell death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.