ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Learning-dependent structural plasticity in the adult olfactory pathway.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
What it found
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Who cites it
76 citing papers in PubMed, 144 citations in OpenAlex.
- Article
- Generalization of fear learning is shaped by inhibitory sensory processing in mice.Nature communications · 2026Article
- Foxg1 Defines Ventrolateral Zonal Identity by Sustaining Neurogenic Progenitor Potential in the Olfactory Epithelium.Genes to cells : devoted to molecular & cellular mechanisms · 2026Article
- Directing negative emotional states through parallel genetically-distinct basolateral amygdala pathways to ventral striatum subregions.Molecular psychiatry · 2025Article
- Foxg1 and Retinoic Acid Signaling Regulate Zonal Patterning in the Developing Olfactory Epithelium.Development, growth & differentiation · 2025Article
- Article
- Perceptual constancy for an odor is acquired through changes in primary sensory neurons.Science advances · 2024Article
- The influence of olfactory experience on the birthrates of olfactory sensory neurons with specific odorant receptor identities.Genesis (New York, N.Y. : 2000) · 2024Review
- Legacies of salient environmental experiences-insights from chemosensation.Chemical senses · 2024Article
- Circuit formation and sensory perception in the mouse olfactory system.Frontiers in neural circuits · 2024Review
- The Role of the Stimulus in Olfactory Plasticity.Brain sciences · 2023Review
- Article
- Intergenerational response to sperm competition risk in an invasive mammal.Proceedings. Biological sciences · 2023Article
- Chemosensory Ability and Sensitivity in Health and Disease: Epigenetic Regulation and COVID-19.International journal of molecular sciences · 2023Review
- Practical Review of Olfactory Training and COVID-19.Journal of rhinology : official journal of the Korean Rhinologic Society · 2022Review
- Article
- High trait anxiety blocks olfactory plasticity induced by aversive learning.Biological psychology · 2022Article
- The human olfactory bulb processes odor valence representation and cues motor avoidance behavior.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Possible Use of Phytochemicals for Recovery from COVID-19-Induced Anosmia and Ageusia.International journal of molecular sciences · 2021Review
- Modulation of olfactory signal detection in the olfactory epithelium: focus on the internal and external environment, and the emerging role of the immune system.Cell and tissue research · 2021Review
16 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Olfactory learning in humans leads to enhanced perceptual discrimination of odor cues. Examining mouse models of both aversive and appetitive conditioning, we demonstrate a mechanism which may underlie this adult learning phenomenon. Topographically unique spatial wiring of the olfactory system allowed us to demonstrate that emotional learning of odor cues alters the primary sensory representation within the nose and brain of adult mice. Transgenic mice labeled at the M71 odorant receptor (specifically activated by the odorant acetophenone) were behaviorally trained with olfactory-dependent fear conditioning or conditioned place preference using acetophenone. Odor-trained mice had larger M71-specific glomeruli and an increase in M71-specific sensory neurons within the nose compared with mice that were untrained, trained to a non-M71 activating odorant, or had nonassociative pairings of acetophenone. These data indicate that the primary sensory neuron population and its projections may remain plastic in adults, providing a structural mechanism for learning-enhanced olfactory sensitivity and discrimination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.