ArticleJournal of leukocyte biology2009
Role of leptin receptor-induced STAT3 signaling in modulation of intestinal and hepatic inflammation in mice.
Article in Journal of leukocyte biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Lack of association between leptin concentrations and cystic fibrosis: A meta-analysis and regression.Frontiers in endocrinology · 2023Pooled it
- Identification and analysis of immune aging related biomarkers in cartilage and meniscus tissues of osteoarthritis.American journal of clinical and experimental immunology · 2025Article
- Inflammatory response and parasite regulation in acute toxoplasmosis: the role of P2X7 receptor in controlling virulent atypical genotype strain ofFrontiers in immunology · 2024Article
- Changes in Lipid Metabolism Enzymes in Rat Epididymal Fat after Chronic Central Leptin Infusion Are Related to Alterations in Inflammation and Insulin Signaling.International journal of molecular sciences · 2023Article
- Current knowledge of leptin in wound healing: A collaborative review.Frontiers in pharmacology · 2022Review
- Leptin alleviates intestinal mucosal barrier injury and inflammation in obese mice with acute pancreatitis.International journal of obesity (2005) · 2018Article
- Evidence against a role for NLRP3-driven islet inflammation in db/db mice.Molecular metabolism · 2018Article
- Identification of Candidate Genes Related to Inflammatory Bowel Disease Using Minimum Redundancy Maximum Relevance, Incremental Feature Selection, and the Shortest-Path Approach.BioMed research international · 2017Article
- Immunogenomics reveal molecular circuits of diclofenac induced liver injury in mice.Oncotarget · 2016Article
- Adiponectin as an anti-fibrotic and anti-inflammatory adipokine in the liver.Current pathobiology reports · 2015Article
- Leptin's metabolic and immune functions can be uncoupled at the ligand/receptor interaction level.Cellular and molecular life sciences : CMLS · 2015Article
- Effect of metformin on metabolic improvement and gut microbiota.Applied and environmental microbiology · 2014Article
- Immunomodulation of liver injury by Ascaris suum extract in an experimental model of autoimmune hepatitis.Parasitology research · 2014Article
- Leptin deficiency impairs maturation of dendritic cells and enhances induction of regulatory T and Th17 cells.European journal of immunology · 2014Article
- Article
- NAG-1/GDF15 transgenic mouse has less white adipose tissue and a reduced inflammatory response.Mediators of inflammation · 2013Article
- The dynamic interdependence of amebiasis, innate immunity, and undernutrition.Seminars in immunopathology · 2012Review
- Leptin protects host cells from Entamoeba histolytica cytotoxicity by a STAT3-dependent mechanism.Infection and immunity · 2012Article
- Immune mechanisms of Concanavalin A model of autoimmune hepatitis.World journal of gastroenterology · 2012Review
- Adipose tissue promotes a serum cytokine profile related to lower insulin sensitivity after chronic central leptin infusion.PloS one · 2012Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Leptin-deficient ob/ob mice are resistant to dextran sulfate sodium (DSS)-induced colitis and Concanavalin A (Con A)-induced hepatitis. However, the signal transduction pathways involved have not been identified. The present study investigated the effect of leptin-induced STAT3 signaling in the DSS and Con A models. Mice carrying a leptin receptor (LEPR) gene mutant for Y1138 (s/s mice), with abrogated leptin-induced STAT3 signaling, were compared with wild-type (WT) and LEPR-deficient db/db mice. Administration of DSS to s/s mice resulted in a clinical score and colon shortening of intermediate severity compared with disease induced in WT and db/db mice-the latter group having the lowest disease severity. A comparable degree of inflammatory infiltrate and epithelial damage was observed in the colon of WT and s/s mice, and these parameters were reduced in db/db mice. Levels of IFN-gamma, IL-6, IL-10, and TNF-alpha were comparable in the colon of s/s and db/db mice, and a similar trend was observed for CXCL2. s/s and WT mice developed severe liver disease in response to Con A, whereas db/db mice were protected. However, Con A-induced serum IL-6 and TNF-alpha levels in s/s mice mimicked levels observed in db/db rather than WT mice. In conclusion, lack of leptin-induced STAT3 signaling is associated with reduced cytokine production following DSS and Con A administration, but it appears to sensitize mice to the effects of proinflammatory mediators.
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Registered trials
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