ArticleJournal of neurophysiology2009
Why sniff fast? The relationship between sniff frequency, odor discrimination, and receptor neuron activation in the rat.
Article in Journal of neurophysiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
73 citing papers in PubMed, 122 citations in OpenAlex.
- Automated intermittent olfactory stimulation to reduce apnea in preterm infants: results of the PREMODEUR randomized clinical trial.European journal of pediatrics · 2026Trial
- Dexterous single sniffs for ethological active olfaction.Science advances · 2026Article
- Acoustic features of and behavioral responses to emotionally intense mouse vocalizations.Behavioural brain research · 2026Article
- Mice navigate scent trails using predictive policies.bioRxiv : the preprint server for biology · 2025Article
- Recalibrating Olfactory Neuroscience to the Range of Naturally Occurring Odor Concentrations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Dopaminergic signaling to ventral striatum neurons initiates sniffing behavior.Nature communications · 2025Article
- Oscillations in the prefrontal-hippocampal circuit couple to respiration-related oscillations during all phases of a working memory task.Frontiers in behavioral neuroscience · 2025Article
- Breathing orchestrates synchronization of sleep oscillations in the human hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Direct Piriform-to-Auditory Cortical Projections Shape Auditory-Olfactory Integration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Direct piriform-to-auditory cortical projections shape auditory-olfactory integration.bioRxiv : the preprint server for biology · 2024Article
- Cell type-specific and frequency-dependent centrifugal modulation in olfactory bulb output neurons in vivo.Journal of neurophysiology · 2024Article
- Article
- Frequency-dependent centrifugal modulation of the activity of different classes of mitral and tufted cells in olfactory bulb.Journal of neurophysiology · 2023Article
- Organization and engagement of a prefrontal-olfactory network during olfactory selective attention.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Nasal anatomy and sniffing in respiration and olfaction of wild and domestic animals.Frontiers in veterinary science · 2023Review
- State-dependent olfactory processing in freely behaving mice.Cell reports · 2022Article
- Reciprocal processes of sensory perception and social bonding: an integrated social-sensory framework of social behavior.Genes, brain, and behavior · 2022Review
- Long-Range Respiratory and Theta Oscillation Networks Depend on Spatial Sensory Context.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Article
- Sniffing speeds up chemical detection by controlling air-flows near sensors.Nature communications · 2021Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Many mammals display brief bouts of high-frequency (4-10 Hz) sniffing when sampling odors. Given this, high-frequency sniffing is thought to play an important role in odor information processing. Here, we asked what role rapid sampling behavior plays in odor coding and odor discrimination by monitoring sniffing during performance of discrimination tasks under different paradigms and across different levels of difficulty and by imaging olfactory receptor neuron (ORN) input to the olfactory bulb (OB) during behavior. To eliminate confounds of locomotion and object approach, all experiments were performed in head-fixed rats. Rats showed individual differences in sniffing strategies that emerged during discrimination learning, with some rats showing brief bouts of rapid sniffing on odorant onset and others showing little or no change in sniff frequency. All rats performed with high accuracy, indicating that rapid sniffing is not necessary for odor discrimination. Sniffing strategies remained unchanged even when task difficulty was increased. In the imaging experiments, rapid sniff bouts did not alter the magnitude of odorant-evoked inputs compared with trials in which rapid sniffing was not expressed. Furthermore, rapid sniff bouts typically began before detectable activation of ORNs and ended immediately afterward. Thus rapid sniffing did not enable multiple samples of an odorant before decision-making. These results suggest that the major functional contribution of rapid sniffing to odor discrimination performance is to enable the animal to acquire the stimulus more quickly once it is available rather than to directly influence the low-level neural processes underlying odor perception.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.