ArticleDigestive diseases and sciences2009
Seasonality in flares and months of births of patients with ulcerative colitis in a Chinese population.
Article in Digestive diseases and sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Pooled it
- Article
- Insolation and Disease Severity in Paediatric Inflammatory Bowel Disease-A Multi-Centre Cross-Sectional Study.Journal of clinical medicine · 2020Article
- An NF-κB-driven lncRNA orchestrates colitis and circadian clock.Science advances · 2020Article
- Seasonal Clock Changes Are Underappreciated Health Risks-Also in IBD?Frontiers in medicine · 2019Article
- Age at onset is associated with the seasonal pattern of onset and exacerbation in inflammatory bowel disease.Journal of gastroenterology · 2017Observational
- The Impact of Cold Spells on the Incidence of Infectious Gastroenteritis and Relapse Rates of Inflammatory Bowel Disease: A Retrospective Controlled Observational Study.Inflammatory intestinal diseases · 2017Article
- Seasonal variations in onset and exacerbation of inflammatory bowel diseases in children.BMC research notes · 2015Article
- Seasonal Variation in Flares of Intestinal Behçet's Disease.Digestive diseases and sciences · 2015Article
- Seasonal variation in months of birth and symptom flares in Korean patients with inflammatory bowel disease.Gut and liver · 2013Article
- Linking vitamin d deficiency to inflammatory bowel disease.Inflammatory bowel diseases · 2013Review
- Month of birth, vitamin D and risk of immune-mediated disease: a case control study.BMC medicine · 2012Article
- Influence of photoperiod on hormones, behavior, and immune function.Frontiers in neuroendocrinology · 2011Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsReports on seasonality in flares or months of births of inflammatory bowel disease patients have been inconsistent, but little data are available in a Chinese population. The aim of this study was to determine whether symptom flares and births of ulcerative colitis (UC) patients follow a seasonal pattern.
methodsPatients with a diagnosis of UC established between January 1990 and December 2007 were investigated according to the occurrence of flares of symptoms and months of births. The expected flares or births were calculated on a monthly basis over the study period, taking into consideration the difference in the number of days in the month in each year.
resultsA total of 409 UC patients were included in the study, and 1030 flares of symptoms were determined. The peak number of flares occurred during the spring and summer, especially in June, while the nadir occurred in the winter, especially in January (chi(2) ((11 df))=32.74304, P<0.005). The symptom flares also occurred more frequently in the spring-summer period than in the autumn-winter period (chi(2) ((3 df))=22.1269, P<0.001). There was no statistical difference in birth distribution on a monthly or seasonal (spring, summer, autumn, winter) basis. However, the births of UC patients occurred more frequently in the autumn-winter period than in the spring-summer period when the data were merged into these two seasonal components (chi(2) ((1 df))=5.255607, P<0.025).
conclusionsThe data indicate that the symptom flares of UC occurred more frequently in the spring and summer, while the births of UC patients occurred more often in the autumn and winter. Environmental recurring factors may be associated with the symptom flares of UC, and these factors during pregnancy or postpartum may be associated with susceptibility to UC later in life.
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