Evidence map›Paper›PMID 19051010›Full record

ReviewHeart failure reviews2010

Biomarkers in heart failure: a clinical review.

J Paul Rocchiccioli, John J V McMurray, Anna F Dominiczak

Abstract readReview
PubMed Publisher
In one paragraph

Review in Heart failure reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. A multicentre analysis of troponin use in clinical practice.Irish journal of medical science · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

J Paul RocchiccioliBHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, G12 8TA, Scotland, UK. p.rocchiccioli@clinmed.gla.ac.uk
John J V McMurray
Anna F Dominiczak

Funding

British Heart Foundation PG/02/128
6 · The paper itself

Abstract

The diagnosis and management of heart failure remains challenging despite considerable clinical advances in recent decades. With greater understanding of the pathophysiology of this complex syndrome, a large number of candidate biomarkers have emerged and duly received scientific and clinical attention. These are frequently a measure of the degree of pathophysiological derangement or counter-regulatory processes occurring in heart failure and include biomarkers of neurohormonal activation, myocyte necrosis and myocardial remodelling amongst others. As such they may serve as an indicator of the presence, severity and possibly therapeutic response of the heart failure syndrome and may complement conventional clinical measurements and acumen. This may in turn lead to tangible clinical benefits and the targeting of intensified and often costly therapies to those most at risk. This article reviews and summarises the most extensively investigated biomarkers currently available, with an emphasis on clinical applicability and discusses the future evaluation of candidate biomarkers in patients with heart failure.

Indexed as

BiomarkersCardiotonic AgentsEmergency Service, HospitalHeart FailureHumansHypertrophy, Left VentricularInflammationNatriuretic AgentsNeurotransmitter AgentsPrognosisRisk AssessmentSyndromeSystoleTreatment OutcomeVentricular Dysfunction, LeftBiomarkersCardiotonic AgentsNatriuretic AgentsNeurotransmitter Agents

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.