SynthesisJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2009
Is gum chewing useful for ileus after elective colorectal surgery? A systematic review and meta-analysis of randomized clinical trials.
Synthesis in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01583452 (Use of Chewing Gum to Reduce Postoperative Ileus in Pediatric Patients After Gastrointestinal Surgery), which is not on this map. Cited by 23 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Use of Chewing Gum to Reduce Postoperative Ileus in Pediatric Patients After Gastrointestinal Surgery
Who cites it
23 citing papers in PubMed, 7 syntheses or guidelines pooled it, 109 citations in OpenAlex.
- Efficacy and safety of therapeutic means for postoperative ileus: an umbrella review of meta-analyses.Langenbeck's archives of surgery · 2025Pooled it
- Effect of chewing gum on clinical outcomes and postoperative recovery in adult patients after gastrointestinal surgery: an umbrella review.International journal of surgery (London, England) · 2025Pooled it
- Pooled it
- Meta-analysis comparing chewing gum versus standard postoperative care after colorectal resection.Oncotarget · 2016Pooled it
- Chewing gum for enhancing early recovery of bowel function after caesarean section.The Cochrane database of systematic reviews · 2016Pooled it
- Chewing gum for postoperative recovery of gastrointestinal function.The Cochrane database of systematic reviews · 2015Pooled it
- Guidelines for perioperative care for pancreaticoduodenectomy: Enhanced Recovery After Surgery (ERAS®) Society recommendations.World journal of surgery · 2013Guideline
- Role of Chewing Gum in Reducing Postoperative Ileus after Reversal of Ileostomy: A Randomized Controlled Trial.World journal of surgery · 2021Trial
- Nicotine chewing gum for the prevention of postoperative ileus after colorectal surgery: a multicenter, double-blind, randomised, controlled pilot study.International journal of colorectal disease · 2017Trial
- Effect of Gum Chewing on the Volume and pH of Gastric Contents: A Prospective Randomized Study.Digestive diseases and sciences · 2015Trial
- Effects of chewing gum against postoperative ileus after pancreaticoduodenectomy--a randomized controlled trial.BMC research notes · 2015Trial
- Chewing gums has stimulatory effects on bowel function in patients undergoing cesarean section: a randomized controlled trial.Bosnian journal of basic medical sciences · 2012Trial
- Role of gum chewing on the duration of postoperative ileus following ileostomy closure done for typhoid ileal perforation: a prospective randomized trial.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationTrial
- The Efficacy of Probiotics, Prebiotics, and Synbiotics in Patients Who Have Undergone Abdominal Operation, in Terms of Bowel Function Post-Operatively: A Network Meta-Analysis.Journal of clinical medicine · 2023Review
- The impact of complications after elective colorectal resection within an enhanced recovery pathway.Techniques in coloproctology · 2018Article
- Clinical practice guideline for enhanced recovery after colon and rectal surgery from the American Society of Colon and Rectal Surgeons (ASCRS) and Society of American Gastrointestinal and Endoscopic Surgeons (SAGES).Surgical endoscopy · 2017Article
- Preoperative risk factors for prolonged postoperative ileus after colorectal resection.International journal of colorectal disease · 2017Article
- Chewing Gum for Intestinal Function Recovery after Colorectal Cancer Surgery: A Systematic Review and Meta-Analysis.Gastroenterology research and practice · 2017Review
- Prevention of Paralytic Ileus Utilizing Alvimopan Following Spine Surgery.Orthopedic reviews · 2015Article
- Facilitating return of bowel function after colorectal surgery: alvimopan and gum chewing.Clinics in colon and rectal surgery · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe evaluation of the usefulness of gum chewing for postoperative ileus has given inconclusive results. We evaluated the efficacy of gum chewing in the treatment of ileus after elective colorectal surgery. MATERIALS AND
methodsWe performed a meta-analysis of randomized clinical trials comparing the effect of gum chewing+standard treatment vs. standard treatment on ileus after colorectal surgery. MEDLINE, EMBASE, the Cochrane Controlled Trial Register, and the Cochrane Database of Systematic Reviews were searched until August 2008. Primary outcomes were time to first flatus, time to first passage of feces, and length of hospital stay. The mean difference (MD) in hours was calculated with the random effects model to assess the effect of gum chewing on the outcomes.
resultsSix trials including 244 patients were analyzed. Time to first flatus was significantly reduced with gum chewing+standard treatment compared to standard treatment alone (MD -14 h, 95% confidence interval [95%CI] -23.5 to -4.6). Time to first passage of feces was significantly reduced (MD -25 h, 95%CI -42.3 to -7.7), but the length of hospital stay was only marginally reduced (MD -26.2 h, 95%CI -57.5 to 5.2) with gum chewing.
conclusionIn patients with ileus after colonic surgery, gum chewing in addition to standard treatment significantly reduces the time to first flatus and the time to first passage of feces when compared to standard treatment alone. There is also a trend to reduce the length of hospital stay. Gum chewing should be added to the standard treatment of these patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.