ArticleThe Journal of membrane biology
Two distinct mechanisms of transport through the plasmodial surface anion channel.
Article in The Journal of membrane biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Nutrient stress dramatically increases malaria parasite clag2 copy number to increase host cell permeability and enable pathogen survival.PLoS pathogens · 2025Article
- A High-Throughput Inhibitor Screen Targeting CLAG3 Export and Membrane Insertion on Human Erythrocytes Infected with Malaria Parasites.Pathogens (Basel, Switzerland) · 2025Article
- Novel Ion Channel Genes in Malaria Parasites.Genes · 2024Review
- Unique Properties of Nutrient Channels onPathogens (Basel, Switzerland) · 2023Review
- Optimized Pyridazinone Nutrient Channel Inhibitors Are Potent and Specific Antimalarial Leads.Molecular pharmacology · 2022Article
- Article
- Complex nutrient channel phenotypes despite Mendelian inheritance in a Plasmodium falciparum genetic cross.PLoS pathogens · 2020Article
- An upstream open reading frame (uORF) signals for cellular localization of the virulence factor implicated in pregnancy associated malaria.Nucleic acids research · 2018Article
- Article
- Synergistic Malaria Parasite Killing by Two Types of Plasmodial Surface Anion Channel Inhibitors.PloS one · 2016Article
- Features of Blastocystis spp. in xenic culture revealed by deconvolutional microscopy.Parasitology research · 2015Article
- A CLAG3 mutation in an amphipathic transmembrane domain alters malaria parasite nutrient channels and confers leupeptin resistance.Infection and immunity · 2015Article
- Why do malaria parasites increase host erythrocyte permeability?Trends in parasitology · 2014Review
- High guanidinium permeability reveals dehydration-dependent ion selectivity in the plasmodial surface anion channel.BioMed research international · 2014Article
- Insights gained from P. falciparum cultivation in modified media.TheScientificWorldJournal · 2013Review
- Malaria parasite clag3 genes determine channel-mediated nutrient uptake by infected red blood cells.Cell · 2011Article
- Altered plasmodial surface anion channel activity and in vitro resistance to permeating antimalarial compounds.Biochimica et biophysica acta · 2010Article
- A cell-based high-throughput screen validates the plasmodial surface anion channel as an antimalarial target.Molecular pharmacology · 2010Article
- Malaria parasite mutants with altered erythrocyte permeability: a new drug resistance mechanism and important molecular tool.Future microbiology · 2010Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The plasmodial surface anion channel (PSAC) is a voltage-dependent ion channel on erythrocytes infected with malaria parasites. To fulfill its presumed function in parasite nutrient acquisition, PSAC is permeant to a broad range of charged and uncharged solutes; it nevertheless excludes Na(+) as required to maintain erythrocyte osmotic stability in plasma. Another surprising property of PSAC is its small single-channel conductance (<3 pS in isotonic Cl(-)) in spite of broad permeability to bulky solutes. While exploring the mechanisms underlying these properties, we recently identified interactions between permeating solutes and PSAC inhibitors that suggest the channel has more than one route for passage of solutes. Here, we explored this possibility with 22 structurally diverse solutes and found that each could be classified into one of two categories based on effects on inhibitor affinity, the temperature dependence of these effects and a clear pattern of behavior in permeant solute mixtures. The clear separation of these solutes into two discrete categories suggests two distinct mechanisms of transport through this channel. In contrast to most other broad-permeability channels, selectivity in PSAC appears to be complex and cannot be adequately explained by simple models that invoke sieving through rigid, noninteracting pores.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.