ArticleRheumatology international2009
Pulse electromagnetic fields effects on serum E2 levels, chondrocyte apoptosis, and matrix metalloproteinase-13 expression in ovariectomized rats.
Article in Rheumatology international, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 25 citations in OpenAlex.
- Pulsed electromagnetic fields in knee osteoarthritis: a double blind, placebo-controlled, randomized clinical trial.Rheumatology (Oxford, England) · 2016Trial
- Trial
- Review
- Can Ultrasound Therapy Be an Environmental-Friendly Alternative to Non-Steroidal Anti-Inflammatory Drugs in Knee Osteoarthritis Treatment?Materials (Basel, Switzerland) · 2021Review
- Physicochemical and biomechanical stimuli in cell-based articular cartilage repair.Current rheumatology reports · 2015Review
- Pulsed electromagnetic field stimulates osteoprotegerin and reduces RANKL expression in ovariectomized rats.Rheumatology international · 2013Article
- Effects of pulsed electromagnetic fields on cartilage apoptosis signalling pathways in ovariectomised rats.International orthopaedics · 2011Article
- The therapeutic effect of a pulsed electromagnetic field on the reproductive patterns of male Wistar rats exposed to a 2.45-GHz microwave field.Clinics (Sao Paulo, Brazil) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Observe pulse electromagnetic fields (PEMFs) effects on ovariectomized (OVX) rats, to study the mechanisms of PEMFs therapy for postmenopausal osteoarthritis. Forty-eight female rats were exposed to PEMFs (PEMFs group), administrated E2 and placebo PEMFs (E group), or were treated with placebo PEMFs (OVX and Sham groups). The treatment duration was 30 days after which serum E2 levels, chondrocyte morphology, chondrocyte apoptosis and matrix metalloproteinases-13 expression in knee joint was analyzed. We observed differential chondrocyte formation in each group, and serum E2 content in the PEMFs and E group were significantly higher than the OVX group. The apoptosis index of chondrocytes and the positive index of MMP13 expression in the PEMFs group and E group were significantly lower than the OVX group. PEMFs has a systemic effect on estrogen metabolism in ovariectomized rats, then inhibit chondrocyte apoptosis and downregulate MMP13 expression of knee joint cartilage. It may be the mechanisms by which PEMFs therapy works for on postmenopausal osteoarthritis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.