ArticleEuropean journal of nuclear medicine and molecular imaging2009
Parametric renal blood flow imaging using [15O]H2O and PET.
Article in European journal of nuclear medicine and molecular imaging, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Compartmental modeling for blood flow quantification from dynamicAnnals of nuclear medicine · 2025Pooled it
- Evaluating the effects of diclofenac sodium and etodolac on renal hemodynamics with contrast-enhanced ultrasonography: a pilot study.European journal of clinical pharmacology · 2013Trial
- Automated long axial field of view PET image processing and kinetic modelling with the TurBO toolbox.European journal of nuclear medicine and molecular imaging · 2026Article
- Measurement of renal cortex perfusion: A direct comparison of arterial spin labelling magnetic resonance imaging and [Magnetic resonance in medicine · 2025Article
- Quantitative Total-Body Imaging of Blood Flow with High-Temporal-Resolution Early DynamicJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- Ex Vivo Simultaneous HJournal of imaging · 2024Article
- Optimization of Fair Arterial Spin Labeling Magnetic Resonance Imaging (ASL-MRI) for Renal Perfusion Quantification in Dogs: Pilot Study.Animals : an open access journal from MDPI · 2024Article
- MappingJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024Article
- Total-Body Perfusion Imaging with [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Renal Perfusion, Oxygenation and Metabolism: The Role of Imaging.Journal of clinical medicine · 2023Review
- Quantitative transport mapping (QTM) of the kidney with an approximate microvascular network.Magnetic resonance in medicine · 2021Article
- Quantitative Analysis of Renal Perfusion by Arterial Spin Labeling.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Renal vascular resistance is increased in patients with kidney transplant.BMC nephrology · 2019Article
- Renal statistical map for positron emission tomography with [O-15] water.American journal of nuclear medicine and molecular imaging · 2019Article
- The renal blood flow reserve in healthy humans and patients with atherosclerotic renovascular disease measured by positron emission tomography using [EJNMMI research · 2018Article
- In vivo, label-free, three-dimensional quantitative imaging of kidney microcirculation using Doppler optical coherence tomography.Laboratory investigation; a journal of technical methods and pathology · 2011Article
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Authors and funding
10 authors.
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Abstract
purposeThe quantitative assessment of renal blood flow (RBF) may help to understand the physiological basis of kidney function and allow an evaluation of pathophysiological events leading to vascular damage, such as renal arterial stenosis and chronic allograft nephropathy. The RBF may be quantified using PET with H(2)(15)O, although RBF studies that have been performed without theoretical evaluation have assumed the partition coefficient of water (p, ml/g) to be uniform over the whole region of renal tissue, and/or radioactivity from the vascular space (V(A). ml/ml) to be negligible. The aim of this study was to develop a method for calculating parametric images of RBF (K(1), k(2)) as well as V(A) without fixing the partition coefficient by the basis function method (BFM).
methodsThe feasibility was tested in healthy subjects. A simulation study was performed to evaluate error sensitivities for possible error sources.
resultsThe experimental study showed that the quantitative accuracy of the present method was consistent with nonlinear least-squares fitting, i.e. K(1,BFM)=0.93K(1,NLF)-0.11 ml/min/g (r=0.80, p<0.001), k(2,BFM)=0.96k(2,NLF)-0.13 ml/min/g (r=0.77, p<0.001), and V(A,BFM)=0.92V(A,NLF)-0.00 ml/ml (r=0.97, p<0.001). Values of the Akaike information criterion from this fitting were the smallest for all subjects except two. The quality of parametric images obtained was acceptable.
conclusionThe simulation study suggested that delay and dispersion time constants should be estimated within an accuracy of 2 s. V(A) and p cannot be neglected or fixed, and reliable measurement of even relative RBF values requires that V(A) is fitted. This study showed the feasibility of measurement of RBF using PET with H(2)(15)O.
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