ArticlePloS one2008
High diversity of vacA and cagA Helicobacter pylori genotypes in patients with and without gastric cancer.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- Article
- Lifestyles, genetics, and future perspectives on gastric cancer in east Asian populations.Journal of human genetics · 2021Review
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- Protein-Coding Genes ofGenes · 2021Article
- Integrative and Conjugative Elements ofFrontiers in cellular and infection microbiology · 2020Article
- vacA s1m1 genotype and cagA EPIYA-ABC pattern are predominant among Helicobacter pylori strains isolated from Mexican patients with chronic gastritis.Journal of medical microbiology · 2018Article
- Article
- Article
- Article
- Efficacy of Zinc Sulfate in Peptic Ulcer Disease: A Randomized Double-Blind Clinical Trial Study.Journal of clinical and diagnostic research : JCDR · 2016Article
- vacA Genotype Status of Helicobacter pylori Isolated from Foods with Animal Origin.BioMed research international · 2016Article
- Article
- Gastric cancer research in Mexico: a public health priority.World journal of gastroenterology · 2014Review
- Helicobacter pylori in vegetables and salads: genotyping and antimicrobial resistance properties.BioMed research international · 2014Article
- Virulence Factors of Helicobacter pylori: A Review.Clinical medicine insights. Gastroenterology · 2014Review
- Study of Helicobacter pylori genotype status in saliva, dental plaques, stool and gastric biopsy samples.World journal of gastroenterology · 2012Article
- Pathogenicity island cag, vacA and IS605 genotypes in Mexican strains of Helicobacter pylori associated with peptic ulcers.Annals of clinical microbiology and antimicrobials · 2011Article
- Genomic diversity ofGut microbesArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHelicobacter pylori is associated with chronic gastritis, peptic ulcers, and gastric cancer. The aim of this study was to assess the topographical distribution of H. pylori in the stomach as well as the vacA and cagA genotypes in patients with and without gastric cancer. METHODOLOGY/PRINCIPAL
findingsThree gastric biopsies, from predetermined regions, were evaluated in 16 patients with gastric cancer and 14 patients with dyspeptic symptoms. From cancer patients, additional biopsy specimens were obtained from tumor centers and margins; among these samples, the presence of H. pylori vacA and cagA genotypes was evaluated. Positive H. pylori was 38% and 26% in biopsies obtained from the gastric cancer and non-cancer groups, respectively (p = 0.008), and 36% in tumor sites. In cancer patients, we found a preferential distribution of H. pylori in the fundus and corpus, whereas, in the non-cancer group, the distribution was uniform (p = 0.003). A majority of the biopsies were simultaneously cagA gene-positive and -negative. The fundus and corpus demonstrated a higher positivity rate for the cagA gene in the non-cancer group (p = 0.036). A mixture of cagA gene sizes was also significantly more frequent in this group (p = 0.003). Ninety-two percent of all the subjects showed more than one vacA gene genotype; s1b and m1 vacA genotypes were predominantly found in the gastric cancer group. The highest vacA-genotype signal-sequence diversity was found in the corpus and 5 cm from tumor margins. CONCLUSION/SIGNIFICANCE: High H. pylori colonization diversity, along with the cagA gene, was found predominantly in the fundus and corpus of patients with gastric cancer. The genotype diversity observed across systematic whole-organ and tumor sampling was remarkable. We find that there is insufficient evidence to support the association of one isolate with a specific disease, due to the multistrain nature of H. pylori infection shown in this work.
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