ArticlePloS one2008
Differentially evolved genes of Salmonella pathogenicity islands: insights into the mechanism of host specificity in Salmonella.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 65 citations in OpenAlex.
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- Mutation of hilD in a Salmonella Derby lineage linked to swine adaptation and reduced risk to human health.Scientific reports · 2020Article
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- TheLife science alliance · 2019Article
- Association of Salmonella virulence factor alleles with intestinal and invasive serovars.BMC genomics · 2019Article
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- Distinct fermentation and antibiotic sensitivity profiles exist in salmonellae of canine and human origin.BMC microbiology · 2018Article
- Identification of a new alanine racemase inGut pathogens · 2018Article
- Genomic Analysis of Salmonella enterica Serovar Typhimurium DT160 Associated with a 14-Year Outbreak, New Zealand, 1998-2012.Emerging infectious diseases · 2017Article
- The Type III Secretion System Effector SptP of Salmonella enterica Serovar Typhi.Journal of bacteriology · 2017Article
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Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe species Salmonella enterica (S. enterica) includes many serovars that cause disease in avian and mammalian hosts. These serovars differ greatly in their host range and their degree of host adaptation. The host specificity of S. enterica serovars appears to be a complex phenomenon governed by multiple factors acting at different stages of the infection process, which makes identification of the cause/s of host specificity solely by experimental methods difficult. METHODOLOGY/PRINCIPAL
findingsIn this study, we have employed a molecular evolution and phylogenetics based approach to identify genes that might play important roles in conferring host specificity to different serovars of S. enterica. These genes are 'differentially evolved' in different S. enterica serovars. This list of 'differentially evolved' genes includes genes that encode translocon proteins (SipD, SseC and SseD) of both Salmonella pathogenicity islands 1 and 2 encoded type three secretion systems, sptP, which encodes an effector protein that inhibits the mitogen-activated protein kinase pathway of the host cell, and genes which encode effector proteins (SseF and SifA) that are important in placing the Salmonella-containing vacuole in a juxtanuclear position. CONCLUSIONS/SIGNIFICANCE: Analysis of known functions of these 'differentially evolved genes' indicates that the products of these genes directly interact with the host cell and manipulate its functions and thereby confer host specificity, at least in part, to different serovars of S. enterica that are considered in this study.
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