ArticleBritish journal of cancer2009
Expression of uPAR mRNA in peripheral blood is a favourite marker for metastasis in gastric cancer cases.
Article in British journal of cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Circulating tumor cells (CTCs) detected by RT-PCR and its prognostic role in gastric cancer: a meta-analysis of published literature.PloS one · 2014Pooled it
- O-GlcNAcylation: Crosstalk between Hemostasis, Inflammation, and Cancer.International journal of molecular sciences · 2024Review
- Compared to preoperative plasma levels post-operative urokinase-type plasminogen activator-1 levels are persistently elevated for 6 weeks after minimally invasive colorectal resection.Journal of gastrointestinal oncology · 2023Article
- Human antibody VFrontiers in oncology · 2023Article
- Molecular mechanisms underlying the action of carcinogens in gastric cancer with a glimpse into targeted therapy.Cellular oncology (Dordrecht, Netherlands) · 2022Review
- Review
- uPAR: An Essential Factor for Tumor Development.Journal of Cancer · 2021Review
- Clinical significance of circulating tumor cells in blood from patients with gastric cancer.Annals of gastroenterological surgery · 2017Review
- Liquid biopsy of gastric cancer patients: circulating tumor cells and cell-free nucleic acids.World journal of gastroenterology · 2014Review
- SPRY1 promotes the degradation of uPAR and inhibits uPAR-mediated cell adhesion and proliferation.American journal of cancer research · 2014Article
- Clinical significance of the uPA system in gastric cancer with peritoneal metastasis.European journal of medical research · 2013Article
- Role of urokinase receptor in tumor progression and development.Theranostics · 2013Review
- Mechanisms for nicotine in the development and progression of gastrointestinal cancers.Translational gastrointestinal cancer · 2012Article
- Evaluating the value of uPAR of serum and tissue on patients with cervical cancer.Journal of clinical laboratory analysis · 2012Article
- Article
- Detection of carcinoembryonic antigen messenger RNA in blood using quantitative real-time reverse transcriptase-polymerase chain reaction to predict recurrence of gastric adenocarcinoma.Journal of translational medicine · 2010Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Urokinase-type plasminogen activator receptor (uPAR) plays a central role in the plasminogen activation cascade and participates in extracellular matrix degradation, cell migration and invasion. We evaluated the expression level of uPAR mRNA and the presence of isolated tumour cells (ITCs) in bone marrow (BM) and peripheral blood (PB) in gastric cancer patients and clarified its clinical significance. We assessed specific uPAR mRNA expression by quantitative real-time reverse transcriptase- polymerase chain reaction (RT-PCR) in BM and PB in 846 gastric cancer patients as well as three epithelial cell markers, carcinoembryonic antigen (CEA), cytokeratin (CK)-19 and CK-7. The uPAR mRNA expression in bone marrow and peripheral blood expressed significantly higher than normal controls (P<0.0001). The uPAR mRNA in BM showed concordant expression with the depth of tumour invasion, distant metastasis, and the postoperative recurrence (P=0.015, 0.044 and 0.010, respectively); whereas in PB, we observed more intimate significant association between uPAR expression and clinicopathologic variables, such as depth of tumour invasion, the distant metastasis, the venous invasion and the clinical stage (P=0.009, 0.002, 0.039 and 0.008, respectively). In addition, the uPAR mRNA expression in PB was an independent prognostic factor for distant metastasis by multivariate analysis. We disclosed that it was possible to identify high-risk patients for distant metastasis by measuring uPAR mRNA especially in peripheral blood at the timing of operation in gastric cancer patients.
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