Evidence map›Paper›PMID 19050672›Full record

ReviewInternational journal of obesity (2005)2009

Emerging role of adipose tissue hypoxia in obesity and insulin resistance.

J Ye

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of obesity (2005), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 254 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
254citing papers in PubMed, 3 pooled it
15.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

254 citing papers in PubMed, 3 syntheses or guidelines pooled it, 523 citations in OpenAlex.

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  16. Protective association of theFrontiers in medicine · 2026
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194 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

J YeGene Regulation Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA.
Pennington Biomedical Research Center · US

Funding

Mechanism of IKK in FFA-associated Insulin ResistanceR01DK068036 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI YE, JIANPING · 2004 to 2013
$2.7M
Regulation of Energy Expenditure by NF-kBR56DK068036 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI YE, JIANPING · 2009 to 2015
$296k
NIDDK NIH HHS DK 68036NIDDK NIH HHS R01 DK068036NIDDK NIH HHS R56 DK068036
6 · The paper itself

Abstract

Recent studies consistently support a hypoxia response in the adipose tissue in obese animals. The observations have led to the formation of an exciting concept, adipose tissue hypoxia (ATH), in the understanding of major disorders associated with obesity. ATH may provide cellular mechanisms for chronic inflammation, macrophage infiltration, adiponectin reduction, leptin elevation, adipocyte death, endoplasmic reticulum stress and mitochondrial dysfunction in white adipose tissue in obesity. The concept suggests that inhibition of adipogenesis and triglyceride synthesis by hypoxia may be a new mechanism for elevated free fatty acids in the circulation in obesity. ATH may represent a unified cellular mechanism for a variety of metabolic disorders and insulin resistance in patients with metabolic syndrome. It suggests a new mechanism of pathogenesis of insulin resistance and inflammation in obstructive sleep apnea. In addition, it may help us to understand the beneficial effects of caloric restriction, physical exercise and angiotensin II inhibitors in the improvement of insulin sensitivity. In this review article, literatures are reviewed to summarize the evidence and possible cellular mechanisms of ATH. The directions and road blocks in the future studies are analyzed.

Indexed as

AdiponectinAdipose TissueAnimalsHumansHypoxiaInflammationInsulin ResistanceLeptinMiceNeovascularization, PhysiologicObesitySignal TransductionAdiponectinLeptin

Identifiers

PMID19050672
PMCPMC2650750
OpenAlexW1970787934

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.