ArticleReproductive sciences (Thousand Oaks, Calif.)2008
Profiling gene expression in human placentae of different gestational ages: an OPRU Network and UW SCOR Study.
Article in Reproductive sciences (Thousand Oaks, Calif.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
82 citing papers in PubMed, 5 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- Sex-based differences in placental DNA methylation profiles related to gestational age: an NIH ECHO meta-analysis.Epigenetics · 2023Pooled it
- Evaluation of Fetal Exposures to Metals and Metalloids through Meconium Analyses: A Review.International journal of environmental research and public health · 2021Pooled it
- Current approaches and developments in transcript profiling of the human placenta.Human reproduction update · 2020Pooled it
- Meta-Analysis of Placental Transcriptome Data Identifies a Novel Molecular Pathway Related to Preeclampsia.PloS one · 2015Pooled it
- Differentially expressed genes in the pre-eclamptic placenta: a systematic review and meta-analysis.PloS one · 2013Pooled it
- Trial
- Differences in gene expression between first and third trimester human placenta: a microarray study.PloS one · 2012Trial
- ESRRG downregulation in early spontaneous abortion induces mitochondrial damage, leading to impaired trophoblast function.Annals of medicine · 2026Article
- Recapitulating gestational progression: a high-throughput 3D bioprinted vascularized human placenta demonstrating stage-specific molecular and functional signatures of human pregnancy.Scientific reports · 2026Article
- NLRP3 inflammasome characterization in first-trimester, preterm, and term human villous placenta.Scientific reports · 2026Article
- Potential Link Between a DisruptiveInternational journal of molecular sciences · 2026Article
- The endothelin-1 system among high-risk pregnant women with obstructive sleep apnea.Journal of sleep research · 2025Article
- Machine learning-derived prognostic signature integrating programmed cell death and mitochondrial function in renal clear cell carcinoma: identification of PIF1 as a novel target.Cancer immunology, immunotherapy : CII · 2025Article
- The Role of Sphingolipid Metabolism in Pregnancy-Associated Breast Cancer After Chemotherapy.Biomedicines · 2024Article
- Rad-mediated inhibition of CaThe Journal of physiology · 2024Article
- MCM proteins are up-regulated in placentas of women with reduced insulin sensitivity.Bioscience reports · 2024Article
- Syncytiotrophoblast Markers Are Downregulated in Placentas from Idiopathic Stillbirths.International journal of molecular sciences · 2024Article
- High-throughput mRNA-seq atlas of human placenta shows vast transcriptome remodeling from first to third trimester†.Biology of reproduction · 2024Article
- GateView: A Multi-Omics Platform for Gene Feature Analysis of Virus Receptors within Human Normal Tissues and Tumors.Biomolecules · 2024Article
- Genome-wide identification of transcriptional enhancers during human placental development and association with function, differentiation, and disease†.Biology of reproduction · 2023Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
We used the whole-genome approach to identify major functional categories of genes whose expression depends on gestational age. Using microarray analysis, we compared gene expression profiles in the villous tissues of first (45-59 days) and second trimester (109-115 days) placentae with C-section term placentae. We found that in first trimester placentae, genes related to cell cycle, DNA, amino acids, and carbohydrate metabolism were significantly overrepresented, while genes related to signal transduction were underrepresented. Among genes involved in organism defense, we identified genes involved in chemical response, metabolism, and transport. Analysis of signal transduction pathways suggested, and subsequently confirmed independently, that the Wnt pathway was changed with gestational age leading to inhibition of beta-catenin protein expression. Our study will serve as a reference database to gain insight into the regulation of gene expression in the developing placentae and to compare with gene expression in placentae from complicated pregnancies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.