ArticleJournal of lipid research2009
The ins (cell) and outs (plasma) of apolipoprotein A-V.
Article in Journal of lipid research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- A Clinical Case of a Homozygous Deletion in theGenes · 2022Article
- Apolipoprotein A-V is a potential target for treating coronary artery disease: evidence from genetic and metabolomic analyses.Journal of lipid research · 2022Article
- Differential Expression of Serum Proteins in Chronic Obstructive Pulmonary Disease Assessed Using Label-Free Proteomics and Bioinformatics Analyses.International journal of chronic obstructive pulmonary disease · 2022Article
- Article
- Sequence Analysis ofFrontiers in genetics · 2018Article
- Review
- Apolipoprotein A-V is present in bile and its secretion increases with lipid absorption in Sprague-Dawley rats.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- Article
- Effects of apolipoprotein A5 haplotypes on the ratio of triglyceride to high-density lipoprotein cholesterol and the risk for metabolic syndrome in Koreans.Lipids in health and disease · 2014Article
- Cloning and characterization of a novel apolipoprotein gene, apolipoprotein AV, in tree shrews.Molecular biology reports · 2013Article
- Influence of apolipoprotein A-V on the metabolic fate of triacylglycerol.Current opinion in lipidology · 2013Review
- Can plasma bile salt, triglycerides, and apoA-V levels predict liver regeneration?World journal of surgery · 2012Article
- APOA5 Q97X mutation identified through homozygosity mapping causes severe hypertriglyceridemia in a Chilean consanguineous family.BMC medical genetics · 2012Article
- Vitamin D dependent effects of APOA5 polymorphisms on HDL cholesterol.Atherosclerosis · 2012Article
- Apolipoprotein A-V dependent modulation of plasma triacylglycerol: a puzzlement.Biochimica et biophysica acta · 2012Review
- Biogenesis of apolipoprotein A-V and its impact on VLDL triglyceride secretion.Journal of lipid research · 2011Article
- Intravenous injection of apolipoprotein A-V reconstituted high-density lipoprotein decreases hypertriglyceridemia in apoav-/- mice and requires glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1.Arteriosclerosis, thrombosis, and vascular biology · 2010Article
- The carboxyl-terminal segment of apolipoprotein A-V undergoes a lipid-induced conformational change.Biochemistry · 2010Article
- Apolipoprotein A-V associates with intrahepatic lipid droplets and influences triglyceride accumulation.Biochimica et biophysica acta · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Apolipoprotein A-V (apoA-V) has a close interrelationship with plasma triglyceride (TG). Since the discovery of the apoA-V gene in 2001, we have learned that single nucleotide polymorphisms in this gene correlate with altered plasma TG levels in humans, while genetically engineered mice manifest unique TG phenotypes. Studies of recombinant apoA-V protein have revealed that it is composed of two independently folded structural domains. The C-terminal domain possesses high lipid binding affinity, while the N-terminal domain adopts a helix bundle molecular architecture. A sequence element with high positive charge character, between residues 185 and 228, functions in binding of apoA-V to heparan sulfate proteoglycans as well as to members of the low-density lipoprotein receptor family and glycosylphosphatidylinositol high-density lipoprotein binding protein1. These interactions may be related to the capacity of this protein to regulate TG levels. ApoA-V is poorly secreted from transfected cultured hepatoma cell lines and is present in plasma at exceedingly low levels. Studies of apoA-V intracellular trafficking revealed an association with cytosolic lipid droplets. Thus, it is conceivable that apoA-V may also modulate TG metabolism within the cell. Much remains to be learned about this fascinating yet confounding member of the class of exchangeable apolipoproteins.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.