ArticleJournal of immunology (Baltimore, Md. : 1950)2008
Regulation of repertoire development through genetic control of DH reading frame preference.
Article in Journal of immunology (Baltimore, Md. : 1950), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The trial behind it
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Who cites it
31 citing papers in PubMed, 37 citations in OpenAlex.
- Trial
- Absent the pre-B cell receptor checkpoint, the B-1a immunoglobulin CDR-H3 repertoire normalizes by convergent selection.Frontiers in immunology · 2026Article
- VH-replacement shapes the antibody repertoire by removing the genes of non-functional heavy-chains.The EMBO journal · 2025Article
- Unveiling inverted D genes and D-D fusions in human antibody repertoires unlocks novel antibody diversity.Communications biology · 2025Article
- Replacement of TCR Dβ With Immunoglobulin DFrontiers in immunology · 2020Article
- Preimmune Control of the Variance of TCR CDR-B3: Insights Gained From Germline Replacement of a TCR Dβ Gene Segment With an Ig DFrontiers in immunology · 2020Article
- A Broad Role for Cysteines in Bovine Antibody Diversity.ImmunoHorizons · 2019Article
- On being the right size: antibody repertoire formation in the mouse and human.Immunogenetics · 2018Review
- In the Absence of Central pre-B Cell Receptor Selection, Peripheral Selection Attempts to Optimize the Antibody Repertoire by Enriching for CDR-H3 Y101.Frontiers in immunology · 2018Article
- The structure of a LAIR1-containing human antibody reveals a novel mechanism of antigen recognition.eLife · 2017Article
- VpreB serves as an invariant surrogate antigen for selecting immunoglobulin antigen-binding sites.Science immunology · 2016Article
- Conservation and diversity in the ultralong third heavy-chain complementarity-determining region of bovine antibodies.Science immunology · 2016Article
- HIV-1 gp140 epitope recognition is influenced by immunoglobulin DH gene segment sequence.Immunogenetics · 2016Article
- The role of evolutionarily conserved germ-line DH sequence in B-1 cell development and natural antibody production.Annals of the New York Academy of Sciences · 2015Review
- Article
- Differences in the composition of the human antibody repertoire by B cell subsets in the blood.Frontiers in immunology · 2014Article
- The Antibody Germline/Maturation Hypothesis, Elicitation of Broadly Neutralizing Antibodies Against HIV-1 and Cord Blood IgM Repertoires.Frontiers in immunology · 2014Article
- The restricted DH gene reading frame usage in the expressed human antibody repertoire is selected based upon its amino acid content.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- The link between antibodies to OxLDL and natural protection against pneumococci depends on D(H) gene conservation.The Journal of experimental medicine · 2013Article
- Recirculating bone marrow B cells in C57BL/6 mice are more tolerant of highly hydrophobic and highly charged CDR-H3s than those in BALB/c mice.European journal of immunology · 2013Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
Abstract
In jawed vertebrates most expressed Ig H chains use only one of six possible D(H) reading frames. Reading frame (RF)1, the preferred reading frame, tends to encode tyrosine and glycine, whereas the other five RFs tend to be enriched for either hydrophobic or charged amino acids. Mechanisms proposed to favor use of RF1 include a preference for deletion over inversion that discourages use of inverted RF1, RF2, and RF3; sequence homology between the 5' terminus of the J(H) and the 3' terminus of the D(H) that promotes rearrangement into RF1; an ATG start site upstream of RF2 that permits production of a truncated Dmicro protein; stop codons in RF3; and, following surface expression of IgM, somatic, presumably Ag receptor-based selection favoring B cells expressing Igs with tyrosine- and glycine-enriched CDR-H3s. By creating an IgH allele limited to the use of a single, frameshifted DFL16.1 D(H) gene segment, we tested the relative contribution of these mechanisms in determining reading frame preference. Dmicro-mediated suppression via an allelic exclusion-like mechanism dominated over somatic selection in determining the composition of the CDR-H3 repertoire. Evidence of somatic selection for RF1-encoded tyrosine in CDR-H3 was observed, but only among the minority of recirculating, mature B cells that use D(H) in RF1. These observations underscore the extent to which the sequence of the D(H) acts to delimit the diversity of the Ab repertoire.
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Registered trials
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