ArticleJournal of immunology (Baltimore, Md. : 1950)2008
Antigenic experience dictates functional role of glycogen synthase kinase-3 in human CD4+ T cell responses.
Article in Journal of immunology (Baltimore, Md. : 1950), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Dual phosphorylation of glycogen synthase kinase 3β differentially integrates metabolic programs to determine T cell immunity across vertebrates.Cellular and molecular life sciences : CMLS · 2025Article
- Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells.Frontiers in immunology · 2023Review
- Inhibition of glycogen synthase kinase 3 by lithium, a mechanism in search of specificity.Frontiers in molecular neuroscience · 2022Review
- Tregs in Autoimmunity: Insights Into Intrinsic Brake Mechanism Driving Pathogenesis and Immune Homeostasis.Frontiers in immunology · 2022Review
- Decreased Levels of STAT1 and Interferon-γ-Induced STAT1 Phosphorylation in Rheumatoid Arthritis CD4 and CD8 T Cells.ACR open rheumatology · 2021Article
- Re-Programming Autoreactive T Cells Into T-Regulatory Type 1 Cells for the Treatment of Autoimmunity.Frontiers in immunology · 2021Review
- Cutting Edge: Inhibition of Glycogen Synthase Kinase 3 Activity Induces the Generation and Enhanced Suppressive Function of Human IL-10Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- The Role of GSK3β in T Lymphocytes in the Tumor Microenvironment.Frontiers in oncology · 2020Review
- Increased prefrontal cortex interleukin-2 protein levels and shift in the peripheral T cell population in progressive supranuclear palsy patients.Scientific reports · 2019Article
- CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation.Cancer discovery · 2018Article
- TGF-β inhibits IL-7-induced proliferation in memory but not naive human CD4Journal of leukocyte biology · 2017Article
- Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter.European journal of immunology · 2015Article
- Convergence of the mammalian target of rapamycin complex 1- and glycogen synthase kinase 3-β-signaling pathways regulates the innate inflammatory response.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Glycogen synthase kinase 3: a point of convergence for the host inflammatory response.Cytokine · 2011Review
- The role of glycogen synthase kinase 3 in regulating IFN-β-mediated IL-10 production.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- What Are the bona fide GSK3 Substrates?International journal of Alzheimer's disease · 2011Article
- Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders.Pharmacology & therapeutics · 2010Review
- Sphingosine kinase-1 is required for toll mediated beta-defensin 2 induction in human oral keratinocytes.PloS one · 2010Article
- Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3).Trends in immunology · 2010Review
- c-jun controls the ability of IL-12 to induce IL-10 production from human memory CD4+ T cells.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Signals induced by the TCR and CD28 costimulatory pathway have been shown to lead to the inactivation of the constitutively active enzyme, glycogen synthase kinase-3 (GSK3), which has been implicated in the regulation of IL-2 and T cell proliferation. However, it is unknown whether GSK3 plays a similar role in naive and memory CD4(+) T cell responses. Here we demonstrate a divergence in the dependency on the inactivation of GSK3 in the proliferative responses of human naive and memory CD4(+) T cells. We find that although CD28 costimulation increases the frequency of phospho-GSK3 inactivation in TCR-stimulated naive and memory CD4(+) T cells, memory cells are less reliant on GSK3 inactivation for their proliferative responses. Rather we find that GSK3beta plays a previously unrecognized role in the selective regulation of the IL-10 recall response by human memory CD4(+) T cells. Furthermore, GSK3beta-inactivated memory CD4(+) T cells acquired the capacity to suppress the bystander proliferation of CD4(+) T cells in an IL-10-dependent, cell contact-independent manner. Our findings reveal a dichotomy present in the function of GSK3 in distinct human CD4(+) T cell populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.