ArticleJournal of immunology (Baltimore, Md. : 1950)2008
Modeling the role of homologous receptor desensitization in cell gradient sensing.
Article in Journal of immunology (Baltimore, Md. : 1950), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A meta-analysis indicates that the regulation of cell motility is a non-intrinsic function of chemoattractant receptors that is governed independently of directional sensing.Frontiers in immunology · 2022Pooled it
- Competing chemical gradients change chemotactic dynamics and cell distribution.Physical review. E · 2026Article
- Signaling dynamics distinguish high- and low-priority neutrophil chemoattractant receptors.Science signaling · 2023Article
- Understanding fibrosis pathogenesis via modeling macrophage-fibroblast interplay in immune-metabolic context.Nature communications · 2022Article
- Altered CXCR4 dynamics at the cell membrane impairs directed cell migration in WHIM syndrome patients.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Signal integration in forward and reverse neutrophil migration: Fundamentals and emerging mechanisms.Current opinion in cell biology · 2021Review
- The spatio-temporal control of effector T cell migration.Nature reviews. Immunology · 2021Review
- Simulating CXCR5 Dynamics in Complex Tissue Microenvironments.Frontiers in immunology · 2021Article
- Gradient-dependent inhibition of stimulatory signaling from platelet G protein-coupled receptors.Haematologica · 2019Article
- Osteoblast migration in vertebrate bone.Biological reviews of the Cambridge Philosophical Society · 2018Review
- Distinctive expression of T cell guiding molecules in human autoimmune lymph node stromal cells upon TLR3 triggering.Scientific reports · 2018Article
- Characterization of EGF-guided MDA-MB-231 cell chemotaxis in vitro using a physiological and highly sensitive assay system.PloS one · 2018Article
- Article
- A Novel Computational Model Predicts Key Regulators of Chemokine Gradient Formation in Lymph Nodes and Site-Specific Roles for CCL19 and ACKR4.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Systems Analysis of the Dynamic Inflammatory Response to Tissue Damage Reveals Spatiotemporal Properties of the Wound Attractant Gradient.Current biology : CB · 2016Article
- Article
- Cross-desensitization of CCR1, but not CCR2, following activation of the formyl peptide receptor FPR1.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Oscillatory behavior of neutrophils under opposing chemoattractant gradients supports a winner-take-all mechanism.PloS one · 2014Article
- Convolution of chemoattractant secretion rate, source density, and receptor desensitization direct diverse migration patterns in leukocytes.Integrative biology : quantitative biosciences from nano to macro · 2013Article
- A model for migratory B cell oscillations from receptor down-regulation induced by external chemokine fields.Bulletin of mathematical biology · 2013Article
Corrections and comments
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2 authors.
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Abstract
G-protein-coupled chemoattractant receptors signal transiently upon ligand binding to effect cell orientation and motility but then are rapidly desensitized. The importance of desensitization has been unclear, because mutated nondesensitizable receptors mediate efficient chemotaxis. We hypothesized that homologous receptor desensitization is required for cellular navigation in fields of competing attractants. Modeling of receptor-mediated orientation shows that desensitization allows integration of attractant signals. Cells expressing normal receptors are predicted to 1) orient preferentially to distant gradients; 2) seek an intermediate position between balanced agonist sources; 3) and can be repositioned between chemoattractant-defined microenvironmental domains by modest changes in receptor number. In contrast, in the absence of desensitization, orientation is dominated by local agonist sources, precluding continued navigation. Furthermore, cell orientation in competing ligand gradients depends on the relative kinetic rates of receptor desensitization and recycling. We propose that homologous receptor desensitization is critical for cellular navigation in complex chemoattractant fields.
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