ReviewSeminars in cancer biology2009
Chemokines and the microenvironment in neuroectodermal tumor-host interaction.
Review in Seminars in cancer biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- The roles of cancer stem cells and therapeutic implications in melanoma.Frontiers in immunology · 2024Review
- Heterogeneous circulating tumor cells correlate with responses to neoadjuvant chemotherapy and prognosis in patients with locally advanced breast cancer.Breast cancer research and treatment · 2023Article
- PathCNN: interpretable convolutional neural networks for survival prediction and pathway analysis applied to glioblastoma.Bioinformatics (Oxford, England) · 2021Article
- Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy.Nature communications · 2021Article
- Neuroblastoma patient-derived cultures are enriched for a mesenchymal gene signature and reflect individual drug response.Cancer science · 2020Article
- Article
- Dynamic monitoring of CD45-/CD31+/DAPI+ circulating endothelial cells aneuploid for chromosome 8 during neoadjuvant chemotherapy in locally advanced breast cancer.Therapeutic advances in medical oncology · 2020Article
- A Computational Framework for Genome-wide Characterization of the Human Disease Landscape.Cell systems · 2019Article
- Macrophages in skin melanoma-the key element in melanomagenesis.Oncology letters · 2018Article
- The role of tumor microenvironment in melanoma therapy resistance.Melanoma management · 2016Review
- Sex differences in the relationship of IL-6 signaling to cancer cachexia progression.Biochimica et biophysica acta · 2015Article
- Mesenchymal stromal cell secretome up-regulates 47 kDa CXCR4 expression, and induce invasiveness in neuroblastoma cell lines.PloS one · 2015Article
- Resveratrol Protects PC12 Cell against 6-OHDA Damage via CXCR4 Signaling Pathway.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Tumor macroenvironment and metabolism.Seminars in oncology · 2014Review
- Crossing the endothelial barrier during metastasis.Nature reviews. Cancer · 2013Review
- One cell, multiple roles: contribution of mesenchymal stem cells to tumor development in tumor microenvironment.Cell & bioscience · 2013Article
- Article
- IRF-8 controls melanoma progression by regulating the cross talk between cancer and immune cells within the tumor microenvironment.Neoplasia (New York, N.Y.) · 2012Article
- Tissue-specific homing of immune cells in malignant skin tumors.Pathology oncology research : POR · 2012Review
- Chemokine signaling directs trunk lymphatic network formation along the preexisting blood vasculature.Developmental cell · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Chemokines and chemokine receptors play an important role in immune homeostasis and surveillance. Altered or defective expression of chemokines and/or chemokine receptors could lead to a disease state including autoimmune disorder or cancer. Tumors from glioblastoma, melanoma, and neuroblastoma secrete high levels of chemokines that can promote tumor growth and progression or induce stromal cells present in the tumor microenvironment to produce cytokines or chemokines which, in turn, can regulate angiogenesis, tumor growth, and metastasis. On the other hand, chemokines secreted by tumor or stromal cells can also attract leukocytes such as dendritic cells, macrophages, neutrophils, and lymphocytes which may downmodulate tumor growth. New therapies that are aimed at limiting tumor growth and progression by attracting immune effector cells to the tumor site with chemokines may hold the key to the successful treatment of cancer, although this approach may be hampered by possible tumor growth-stimulating effects of chemokines.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.