ArticleCurrent microbiology2009
L-methioninase production by filamentous fungi: I-screening and optimization under submerged conditions.
Article in Current microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 51 citations in OpenAlex.
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- Biochemical, molecular and anti-tumor characterization of L-methionine gamma lyase produced by localSaudi journal of biological sciences · 2023Article
- Assessment of the phylogenetic analysis and antimicrobial, antiviral, and anticancer activities of marine endophytic Streptomyces species of the soft coral Sarcophyton convolutum.International microbiology : the official journal of the Spanish Society for Microbiology · 2022Article
- Exploiting the Biosynthetic Potency of Taxol from Fungal Endophytes of Conifers Plants; Genome Mining and Metabolic Manipulation.Molecules (Basel, Switzerland) · 2020Review
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- Purification and Characterization of Ornithine Decarboxylase fromMolecules (Basel, Switzerland) · 2019Article
- Growth of marine fungi on polymeric substrates.BMC biotechnology · 2016Article
- l-Methioninase from someJournal, genetic engineering & biotechnology · 2015Article
- Transcriptional and Proteomic Profiling of Aspergillus flavipes in Response to Sulfur Starvation.PloS one · 2015Article
- Production of scopularide A in submerged culture with Scopulariopsis brevicaulis.Microbial cell factories · 2014Article
- L-methionase: a therapeutic enzyme to treat malignancies.BioMed research international · 2014Review
- Purification and characterization of a new L-methioninase from solid cultures of Aspergillus flavipes.Journal of microbiology (Seoul, Korea) · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Findings show 21 fungal isolates belonging to eight genera recovered from Egyptian soils that have the potential to attack L-methionine under submerged conditions. Aspergillus flavipes had the most methioninolytic activity, giving the highest yield of L-methioninase (10.78 U/mg protein), rate of methionine uptake (93.0%), and growth rate (5.0 g/l), followed by Scopulariopsis brevicaulis and A. carneus. The maximum L-methioninase productivity (11.60 U/mg protein) by A. flavipes was observed using L-methionine (0.8%) as an enzyme-inductive agent and glucose (1%) as a co-dissimilated carbon source. A significant reduction in L-methioninase biosynthesis by A. flavipes was detected using carbon-free medium, suggesting the lack of ability to use L-methionine as a carbon and nitrogen source. Potassium dihydrogen phosphate (0.25%), the best source of phosphorus, favors enzyme biosynthesis and enhances the level of methionine uptake by A. flavipes. The maximum L-methioninase productivity (12.58 U/mg protein) and substrate uptake (95.6%) were measured at an initial pH of 7.0.
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