ArticleLipids2009
Inhibitory effect of conjugated alpha-linolenic acid from bifidobacteria of intestinal origin on SW480 cancer cells.
Article in Lipids, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 73 citations in OpenAlex.
- Infant gut microbiota characteristics generally do not modify effects of lipid-based nutrient supplementation on growth or inflammation: secondary analysis of a randomized controlled trial in Malawi.Scientific reports · 2020Trial
- There may be a differential mechanistic impact on colorectal cancer of lactose-containing foods between lactase persistent and lactase non-persistent populations.Frontiers in nutrition · 2026Review
- Endocrine-targeting therapies shift the breast microbiome to reduce estrogen receptor-α breast cancer risk.Cell reports. Medicine · 2025Article
- Article
- A Comprehensive Review on Biotransformation, Interaction, and Health of Gut Microbiota and Bioactive Components.Combinatorial chemistry & high throughput screening · 2024Review
- Macronutrient balance determines the human gut microbiome eubiosis: insights fromFrontiers in microbiology · 2024Article
- Appraisal of postbiotics in cancer therapy.Frontiers in pharmacology · 2024Review
- Structural analysis and prebiotic activity of exopolysaccharide produced by probiotic strainFood science and biotechnology · 2023Article
- Determination of Commercial Animal and Vegetable Milks' Lipid Profile and Its Correlation with Cell Viability and Antioxidant Activity on Human Intestinal Caco-2 Cells.Molecules (Basel, Switzerland) · 2021Article
- Antiproliferation Activity and Mechanism of c9, t11, c15-CLNA and t9, t11, c15-CLNA fromMolecules (Basel, Switzerland) · 2020Article
- Effect of Pufa Substrates on Fatty Acid Profile of Bifidobacterium breve Ncimb 702258 and CLA/CLNA Production in Commercial Semi-Skimmed Milk.Scientific reports · 2018Article
- Obese Mice Losing Weight Due to trans-10,cis-12 Conjugated Linoleic Acid Supplementation or Food Restriction Harbor Distinct Gut Microbiota.The Journal of nutrition · 2018Article
- Mining bifidobacteria from the neonatal gastrointestinal tract for conjugated linolenic acid production.Bioengineered · 2017Article
- Bifidobacterium breve with α-linolenic acid alters the composition, distribution and transcription factor activity associated with metabolism and absorption of fat.Scientific reports · 2017Article
- Capsular polysaccharide inhibits adhesion ofGut pathogens · 2017Article
- Review
- Milk drinking and mortality: findings from the Japan collaborative cohort study.Journal of epidemiology · 2015Article
- Production of conjugated linoleic and conjugated α-linolenic acid in a reconstituted skim milk-based medium by bifidobacterial strains isolated from human breast milk.BioMed research international · 2014Article
- Role of the lower and upper intestine in the production and absorption of gut microbiota-derived PUFA metabolites.PloS one · 2014Article
- Oral administration of monogalactosyl diacylglycerol from spinach inhibits colon tumor growth in mice.Experimental and therapeutic medicine · 2013Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we assessed the ability of six strains of bifidobacteria (previously shown by us to possess the ability to convert linoleic acid to c9, t11-conjugated linoleic acid (CLA) to grow in the presence of alpha-linolenic acid and to generate conjugated isomers of the fatty acid substrate during fermentation for 42 h. The six strains of bifidobacteria were grown in modified MRS (mMRS) containing alpha-linolenic acid for 42 h at 37 degrees C, after which the fatty acid composition of the growth medium was assessed by gas liquid chromatography (GLC). Indeed, following fermentation of one of the strains, namely Bifidobacterium breve NCIMB 702258, in the presence of 0.41 mg/ml alpha-linolenic acid, 79.1% was converted to the conjugated isomer, C18:3 c9, t11, c15 conjugated alpha-linolenic acid (CALA). To examine the inhibitory effect of the fermented oils produced, SW480 colon cancer cells were cultured in the presence of the extracted fermented oil (10-50 microg/ml) for 5 days. The data indicate an inhibitory effect on cell growth (p <or= 0.001) of CALA, with cell numbers reduced by 85% at a concentration of 180 microM, compared with a reduction of only 50% with alpha-linolenic acid (p <or= 0.01).
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