ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2009
Evaluation of the LightCycler SeptiFast test in the rapid etiologic diagnostic of infectious endocarditis.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- Multiplex PCR system for rapid detection of pathogens in patients with presumed sepsis - a systemic review and meta-analysis.PloS one · 2013Pooled it
- Molecular methods for diagnosis of infective endocarditis.Infectious disease clinics of North America · 2002Guideline
- Syndrome Evaluation System (SES) versus Blood Culture (BACTEC) in the Diagnosis and Management of Neonatal Sepsis--A Randomized Controlled Trial.Indian journal of pediatrics · 2016Trial
- Diagnostic performance of a multiple real-time PCR assay in patients with suspected sepsis hospitalized in an internal medicine ward.Journal of clinical microbiology · 2012Trial
- Rapid molecular assays versus blood culture for bloodstream infections: a systematic review and meta-analysis.EClinicalMedicine · 2025Article
- Accuracy and Impact on Patient Management of New Tools for Diagnosis of Sepsis: Experience with the T2 Magnetic Resonance Bacteria Panel.Pathogens (Basel, Switzerland) · 2021Article
- Emerging Microtechnologies and Automated Systems for Rapid Bacterial Identification and Antibiotic Susceptibility Testing.SLAS technology · 2017Article
- Blood culture-negative endocarditis: Improving the diagnostic yield using new diagnostic tools.Medicine · 2017Article
- SeptiFast versus blood culture in clinical routine - A report on 3 years experience.Wiener klinische Wochenschrift · 2017Observational
- Enrichment of bacterial DNA for the diagnosis of blood stream infections.BMC infectious diseases · 2016Article
- Intracranial Aneurysms From Presumed Infective Endocarditis: The Dilemma of Persistently Negative Cultures.The Neurohospitalist · 2016Article
- A Diagnostic Serum Antibody Test for Patients With Staphylococcus aureus Osteomyelitis.Clinical orthopaedics and related research · 2015Article
- Developments for improved diagnosis of bacterial bloodstream infections.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Review
- Emerging technologies for the clinical microbiology laboratory.Clinical microbiology reviews · 2014Review
- Molecular diagnosis of sepsis: New aspects and recent developments.European journal of microbiology & immunology · 2014Article
- Commercial multiplex technologies for the microbiological diagnosis of sepsis.Molecular diagnosis & therapy · 2013Review
- Comparison of three different commercial PCR assays for the detection of pathogens in critically ill sepsis patients.Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2013Observational
- Bacterial detection & identification using electrochemical sensors.Journal of visualized experiments : JoVE · 2013Article
- The value of combining blood culture and SeptiFast data for predicting complicated bloodstream infections caused by Gram-positive bacteria or Candida species.Journal of clinical microbiology · 2013Article
- Diagnostic performance and therapeutic impact of LightCycler SeptiFast assay in patients with suspected sepsis.European journal of microbiology & immunology · 2013Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The SeptiFast test (Roche Diagnostics) is a new commercial molecular technique that has emerged for the detection of bacteria in blood. We compared in this study the sensitivity of blood culture to a commercially available broad-range real-time polymerase chain reaction (PCR) assay for the detection in blood of 19 bacterial species and six fungal species (SeptiFast test, Roche Diagnostics) in 63 patients with infectious endocarditis (IE). The SeptiFast test is not more sensitive for organisms such as Streptococci, Enterococci, and Staphylococcus aureus (11/29 versus 12/29 for blood culture). It has detected less commonly coagulase-negative Staphylococci (0/15 versus 3/15, P = 0.2) and significantly fewer other microorganisms (0/6 versus 4/6, P = 0.03). However, bacteria were detected from three IE treated by antibiotics, with blood culture negative on admission. The SeptiFast test may be useful in cases of IE in patients treated with antibiotics before admission.
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