ArticleEuropean journal of clinical pharmacology2009
Changes in urinary PGE2 after ibuprofen treatment in preterm infants with patent ductus arteriosus.
Article in European journal of clinical pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Spontaneous Closure of the Ductus Arteriosus in Preterm Infants: A Systematic Review.Frontiers in pediatrics · 2020Pooled it
- Ibuprofen in very preterm infants impairs renal function for the first month of life.Pediatric nephrology (Berlin, Germany) · 2010Trial
- Review
- Sex Differences in Patent Ductus Arteriosus Incidence and Response to Pharmacological Treatment in Preterm Infants: A Systematic Review, Meta-Analysis and Meta-Regression.Journal of personalized medicine · 2022Review
- Patent ductus arteriosus is associated with acute kidney injury in the preterm infant.Pediatric nephrology (Berlin, Germany) · 2019Article
- Efficacy and Safety of Oral Paracetamol vs. Oral Ibuprofen in the Treatment of Symptomatic Patent Ductus Arteriosus in Premature Infants.Paediatric drugs · 2019Article
- Paracetamol in Patent Ductus Arteriosus Treatment: Efficacious and Safe?BioMed research international · 2017Review
- Oral paracetamol vs. oral ibuprofen in the treatment of symptomatic patent ductus arteriosus in premature infants: A randomized controlled trial.Experimental and therapeutic medicine · 2016Article
- Neonatal pharmacology: extensive interindividual variability despite limited size.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2011Article
- Should we definitively abandon prophylaxis for patent ductus arteriosus in preterm new-borns?Clinics (Sao Paulo, Brazil) · 2011Review
- Renal Side Effects of Non-Steroidal Anti-Inflammatory Drugs in Neonates.Pharmaceuticals (Basel, Switzerland) · 2010Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate changes in urinary PGE(2) after ibuprofen treatment in preterm infants with patent ductus arteriosus (PDA).
methodsTwenty preterm infants with a hemodynamically significant PDA (gestational age, 28.6 +/- 2.3 weeks) and 20 controls (gestational age, 30.4 +/- 1.5 weeks) were prospectively enrolled at 48-72 h of life. After enrollment, the former underwent conventional ibuprofen-lysine treatment. At 48-72 h (T(0)) and 108-144 h of life (T(1)), urine samples were noninvasively collected in both groups to measure urinary PGE(2) concentrations (enzyme immunoassay method), and renal function was investigated.
resultsUrinary PGE(2) decreased significantly both in ibuprofen-treated patients (66.95 +/- 16.78 vs. 27.15 +/- 17.92 pg/mL, P < 0.001) and in controls (71.7 +/- 16.2 vs. 53.2 +/- 18.4 pg/mL, P < 0.001) from T(0) to T(1). However, urinary PGE(2) at T(1) was significantly lower (P < 0.001) in the ibuprofen group compared to the control group. Acute renal failure occurred in three ibuprofen-treated patients (15%).
conclusionsIbuprofen markedly reduces (59.4%) urinary PGE(2) and may alter renal function in the newborn.
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