Trial reportExperimental brain research2009
Differing effects of intracortical circuits on plasticity.
Trial report in Experimental brain research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 54 citations in OpenAlex.
- Exploration of NMDA and GABA receptor-mediated plasticity induced by 10-Hz repetitive transcranial magnetic stimulation.Translational psychiatry · 2026Trial
- Fluoxetine does not influence response to continuous theta burst stimulation in human motor cortex.Neuropsychopharmacology reports · 2025Trial
- Effects of the Selective α5-GABAAR Antagonist S44819 on Excitability in the Human Brain: A TMS-EMG and TMS-EEG Phase I Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Trial
- Changes in the cortical GABAergic inhibitory system with ageing and ageing-related neurodegenerative diseases.The Journal of physiology · 2026Review
- Gating of Neuroplasticity: Effects and Mechanisms of Acute Aerobic Exercise as a Brain Stimulation for the Sensorimotor Cortex.Advances in neurobiology · 2025Review
- Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Review
- Transcranial Magnetic Stimulation to Assess Exercise-Induced Neuroplasticity.Frontiers in neuroergonomics · 2021Review
- The Influence of Recreational Substance Use in TMS Research.Brain sciences · 2020Review
- Enhancing Gamma Oscillations Restores Primary Motor Cortex Plasticity in Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Mal de Debarquement Syndrome: A Matter of Loops?Frontiers in neurology · 2020Article
- Biomarkers Obtained by Transcranial Magnetic Stimulation of the Motor Cortex in Epilepsy.Frontiers in integrative neuroscience · 2019Article
- Effects of lorazepam and baclofen on short- and long-latency afferent inhibition.The Journal of physiology · 2018Article
- Cortical inhibitory markers of lifetime suicidal behavior in depressed adolescents.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Decrease in short-latency afferent inhibition during corticomotor postexercise depression following repetitive finger movement.Brain and behavior · 2017Article
- A combined TMS-EEG study of short-latency afferent inhibition in the motor and dorsolateral prefrontal cortex.Journal of neurophysiology · 2016Article
- Augmenting Plasticity Induction in Human Motor Cortex by Disinhibition Stimulation.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- The influence of sensory afferent input on local motor cortical excitatory circuitry in humans.The Journal of physiology · 2015Article
- Corticospinal activity evoked and modulated by non-invasive stimulation of the intact human motor cortex.The Journal of physiology · 2014Review
- Synaptic plasticity and PDGF signaling defects underlie clinical progression in multiple sclerosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Relationship between transcranial magnetic stimulation measures of intracortical inhibition and spectroscopy measures of GABA and glutamate+glutamine.Journal of neurophysiology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Practice of a motor task leads to an increase in amplitude of motor-evoked potentials (MEP) in the exercised muscle. This is termed practice-dependent plasticity, and is abolished by the NMDA antagonist dextromethorphan and the GABA(A) agonist lorazepam. Here, we sought to determine whether specific subtypes of GABA(A) circuits are responsible for this effect by comparing the action of the non-selective agonist, lorazepam with that of the selective GABA(A)-alpha(1) receptor agonist, zolpidem. In seven healthy subjects, transcranial magnetic stimulation (TMS) was used to quantify changes in amplitude of MEP after practice of a ballistic motor task. In addition we measured how the same drugs affected MEP amplitudes and the excitability of a number of cortical inhibitory circuits [short-interval intracortical inhibition (SICI), short-interval afferent inhibition (SAI) and long-interval intracortical inhibition]. This allowed us to explore correlations between drugs effects in measures of cortical excitability and practice-dependent plasticity of MEP amplitudes. As previously reported, lorazepam increased SICI and decreased SAI, while zolpidem only decreased SAI. The new findings were that practice-dependent plasticity of MEPs was impaired by lorazepam but not zolpidem, and that this was negatively correlated with lorazepam-induced changes in SICI but not SAI. This suggests that the intracortical circuits involved in SICI (and not neurons expressing GABA(A)-alpha(1) receptor subunits that are implicated in SAI) may be involved in controlling the amount of practice-dependent MEP plasticity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.