ArticleClinical and experimental medicine2009
Interactions between rs5498 polymorphism in the ICAM1 gene and traditional risk factors influence susceptibility to coronary artery disease.
Article in Clinical and experimental medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Association between theBioscience reports · 2019Pooled it
- Pooled it
- Intercellular adhesion molecule-1 K469E polymorphism and risk of coronary artery disease: a meta-analysis.Medical science monitor : international medical journal of experimental and clinical research · 2014Pooled it
- Intercellular adhesion molecule 1 gene K469E polymorphism is associated with coronary heart disease risk: a meta-analysis involving 12 studies.Molecular biology reports · 2012Pooled it
- Article
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- [Effects of low-intensity pulsed ultrasound on hematopoietic function in rats after combined chemotherapy with doxorubicin and cyclophosphamide].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019Article
- Letter to the Editor: Comments on "Association between the ICAM-1 gene polymorphism and coronary heart disease risk: a meta-analysis".Bioscience reports · 2019Article
- A Allele ofOpen life sciences · 2019Article
- Evaluation of the Obesity Genes FTO and MC4R for Contribution to the Risk of Large Artery Atherosclerotic Stroke in a Chinese Population.Obesity facts · 2016Article
- Integrated systems approach identifies risk regulatory pathways and key regulators in coronary artery disease.Journal of molecular medicine (Berlin, Germany) · 2015Article
- Impact of Intercellular Adhesion Molecule-1 Genetic Polymorphisms on Coronary Artery Disease Susceptibility in Taiwanese Subjects.International journal of medical sciences · 2015Article
- Interaction of intercellular adhesion molecule 1 (ICAM1) polymorphisms and environmental tobacco smoke on childhood asthma.International journal of environmental research and public health · 2014Article
- Correlation between ICAM1 and VCAM1 gene polymorphisms and histopathological changes in kidney allograft biopsies.Archives of medical science : AMS · 2013Article
- Association of inflammatory gene polymorphisms and conventional risk factors with arterial stiffness by age.Journal of epidemiology · 2013Article
- Genetic variations in E-selectin and ICAM-1: relation to atherosclerosis.Medical science monitor : international medical journal of experimental and clinical research · 2012Article
- On the use of variance per genotype as a tool to identify quantitative trait interaction effects: a report from the Women's Genome Health Study.PLoS genetics · 2010Article
- ICAM-1 molecular mechanism and genome wide SNP's association studies.Indian heart journalReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronary artery disease (CAD) depends on multiple genetic and environmental factors. Adhesion molecules are markers of endothelium dysfunction. Intercellular adhesion molecule-1 (ICAM-1) interacts with leukocyte integrins and promotes atherosclerotic process at the surface of endothelial cells. The aim of the study was to assess the association between ICAM1 rs5498 polymorphism and CAD and to establish whether there are any interactions between this polymorphism and traditional risk factors in determining the risk of CAD. We studied 191 cases with angiographically documented CAD and 203 controls with no signs of cardiovascular diseases. The ICAM1 polymorphism was genotyped using PCR-RFLP method. Data were analyzed with the STATISTICA 7.1 and EpiInfo 6 softwares. We did not observe significant differences in the distribution of genotypes and alleles of rs5498 between cases and controls. We only found a tendency to a higher prevalence of G allele carriers (AG + GG) in patients compared to controls (68 vs. 64%, P = 0.399). A synergistic effect of G allele carrier-state and smoking that had influenced the risk of CAD [synergy index multiplicative (SIM = 2.09)] was observed. Smoking carriers of G allele compared to non-smoking AA were more prevalent in CAD group (39.8%) than among controls (13.3%, P < 0.0001, OR 4.81). Moreover, there was also a synergistic effect between G allele carrier-state and an elevated level of triacylglycerols (TG) (SIM = 1.28) increasing the risk of CAD. There is a synergistic interaction between rs5498 genotype and smoking that increases the risk of CAD.
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