ArticlePloS one2008
Colon-derived liver metastasis, colorectal carcinoma, and hepatocellular carcinoma can be discriminated by the Ca(2+)-binding proteins S100A6 and S100A11.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- An integrative omics-guided druggability analysis of VCX2 in hepatocellular carcinoma using Peruvian natural products.Frontiers in bioinformatics · 2026Article
- S100A6 Protein-Expression and Function in Norm and Pathology.International journal of molecular sciences · 2023Review
- Actin Cytoskeletal Dynamics in Single-Cell Wound Repair.International journal of molecular sciences · 2021Review
- Proteomic Characterization of Colorectal Cancer Tissue from Patients Identifies Novel Putative Protein Biomarkers.Current issues in molecular biology · 2021Article
- Long non‑coding RNA FOXD2‑AS1 regulates the tumorigenesis and progression of breast cancer via the S100 calcium binding protein A1/Hippo signaling pathway.International journal of molecular medicine · 2020Article
- Differentially expressed proteins in positive versus negative HNSCC lymph nodes.BMC medical genomics · 2018Article
- MicroRNA‑22 inhibits the proliferation and migration, and increases the cisplatin sensitivity, of osteosarcoma cells.Molecular medicine reports · 2018Article
- S100 Proteins As an Important Regulator of Macrophage Inflammation.Frontiers in immunology · 2017Review
- S100A11 plays a role in homologous recombination and genome maintenance by influencing the persistence of RAD51 in DNA repair foci.Cell cycle (Georgetown, Tex.) · 2016Article
- LASP1-S100A11 axis promotes colorectal cancer aggressiveness by modulating TGFβ/Smad signaling.Scientific reports · 2016Article
- Diagnostic significance of S100A2 and S100A6 levels in sera of patients with non-small cell lung cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Role of S100 Proteins in Colorectal Carcinogenesis.Gastroenterology research and practice · 2016Review
- S100 and annexin proteins identify cell membrane damage as the Achilles heel of metastatic cancer cells.Cell cycle (Georgetown, Tex.) · 2015Article
- The search for the primary tumor in metastasized gastroenteropancreatic neuroendocrine neoplasm.Clinical & experimental metastasis · 2014Article
- S100A11 is required for efficient plasma membrane repair and survival of invasive cancer cells.Nature communications · 2014Article
- Increased expression of S100A6 promotes cell proliferation and migration in human hepatocellular carcinoma.Journal of molecular medicine (Berlin, Germany) · 2014Article
- EGFRvIII mediates hepatocellular carcinoma cell invasion by promoting S100 calcium binding protein A11 expression.PloS one · 2013Article
- A microarray-based gene expression analysis to identify diagnostic biomarkers for unknown primary cancer.PloS one · 2013Article
- S100 proteins as diagnostic and prognostic markers in colorectal and hepatocellular carcinoma.Hepatitis monthly · 2012Article
- Localization of sporadic neuroendocrine tumors by gene expression analysis of their metastases.Clinical & experimental metastasis · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is unknown, on the proteomic level, whether the protein patterns of tumors change during metastasis or whether markers are present that allow metastases to be allocated to a specific tumor entity. The latter is of clinical interest if the primary tumor is not known. METHODOLOGY/PRINCIPAL
findingsIn this study, tissue from colon-derived liver metastases (n = 17) were classified, laser-microdissected, and analysed by ProteinChip arrays (SELDI). The resulting spectra were compared with data for primary colorectal (CRC) and hepatocellular carcinomas (HCC) from our former studies. Of 49 signals differentially expressed in primary HCC, primary CRC, and liver metastases, two were identified by immunodepletion as S100A6 and S100A11. Both proteins were precisely localized immunohistochemically in cells. S100A6 and S100A11 can discriminate significantly between the two primary tumor entities, CRC and HCC, whereas S100A6 allows the discrimination of metastases and HCC.
conclusionsBoth identified proteins can be used to discriminate different tumor entities. Specific markers or proteomic patterns for the metastases of different primary cancers will allow us to determine the biological characteristics of metastasis in general. It is unknown how the protein patterns of tumors change during metastasis or whether markers are present that allow metastases to be allocated to a specific tumor entity. The latter is of clinical interest if the primary tumor is not known.
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