ArticleDisease models & mechanisms
Removing the cloak of invisibility: phenotyping the mouse.
Article in Disease models & mechanisms. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- From gene to treatment: supporting rare disease translational research through model systems.Disease models & mechanisms · 2019Article
- Using association rule mining to determine promising secondary phenotyping hypotheses.Bioinformatics (Oxford, England) · 2014Article
- High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes.Bone research · 2014Article
- Mouse genetic and phenotypic resources for human genetics.Human mutation · 2012Review
- Exploring the elephant: histopathology in high-throughput phenotyping of mutant mice.Disease models & mechanisms · 2012Review
- Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength.PLoS genetics · 2012Article
- Optical Coherence Tomography for live imaging of mammalian development.Current opinion in genetics & development · 2011Review
- Optimising experimental design for high-throughput phenotyping in mice: a case study.Mammalian genome : official journal of the International Mammalian Genome Society · 2010Article
- Mouse mutagenesis with the chemical supermutagen ENU.Methods in enzymology · 2010Article
- Phenotype ontologies for mouse and man: bridging the semantic gap.Disease models & mechanismsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
If you study a human disease, it is likely that you have tried to generate a mouse model. Sometimes, these models are excellent; others are disappointing. Or, so we think. How often does our mouse mutant not model the human disease because of limitations in how we may look at it? In any living organism, many factors work together to produce the phenotype. Here, new phenotyping paradigms for assessing mouse biology and physiology are described and proposed. Advances in mouse phenotype assessments have paralleled human clinical diagnostics. The future brings a multitude of mouse strains that might be exposed to a variety of conditions. To assess health will require the ability to perform a broad-based phenotype assessment of every animal until we can understand how the perturbation of one system affects others.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.