ArticleDisease models & mechanisms
The expanding role of mouse genetics for understanding human biology and disease.
Article in Disease models & mechanisms. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
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- In search for the "idyllic" animal model to evaluate ocular pathologies and translate new therapies to improve human health.Neural regeneration research · 2022Article
- The Underlying Relationship between Keratoconus and Down Syndrome.International journal of molecular sciences · 2022Review
- Herbal Medicines against Hydatid Disease: A Systematic Review (2000-2021).Life (Basel, Switzerland) · 2022Review
- Current Perspectives on Gastrointestinal Models to Assess Probiotic-Pathogen Interactions.Frontiers in microbiology · 2022Review
- Few Fixed Variants between Trophic Specialist Pupfish Species Reveal Candidate Cis-Regulatory Alleles Underlying Rapid Craniofacial Divergence.Molecular biology and evolution · 2021Article
- Fetal Growth Plate Cartilage : Histological and Immunohistochemical Techniques.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Tamoxifen-independent recombination of reporter genes limits lineage tracing and mosaic analysis using CreERTransgenic research · 2020Article
- Exome Sequencing Reveals the POLR3H Gene as a Novel Cause of Primary Ovarian Insufficiency.The Journal of clinical endocrinology and metabolism · 2019Article
- CRISPR/Cas9 - An evolving biological tool kit for cancer biology and oncology.NPJ precision oncology · 2019Review
- Precise and Rapid Validation of Candidate Gene by Allele Specific Knockout With CRISPR/Cas9 in Wild Mice.Frontiers in genetics · 2019Article
- Responses of rat and mouse primary microglia to pro- and anti-inflammatory stimuli: molecular profiles, KJournal of neuroinflammation · 2017Article
- Novel promoters and coding first exons in DLG2 linked to developmental disorders and intellectual disability.Genome medicine · 2017Article
- Vertebrate embryos as tools for anti-angiogenic drug screening and function.Reproductive toxicology (Elmsford, N.Y.) · 2017Review
- Diverse application of MRI for mouse phenotyping.Birth defects research · 2017Review
- X-ray phase microtomography with a single grating for high-throughput investigations of biological tissue.Biomedical optics express · 2017Article
- Ovariectomy results in inbred strain-specific increases in anxiety-like behavior in mice.Physiology & behavior · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
It has taken about 100 years since the mouse first captured our imagination as an intriguing animal for it to become the premier genetic model organism. An expanding repertoire of genetic technology, together with sequencing of the genome and biological conservation, place the mouse at the foremost position as a model to decipher mechanisms underlying biological and disease processes. The combined approaches of embryonic stem cell-based technologies, chemical and insertional mutagenesis have enabled the systematic interrogation of the mouse genome with the aim of creating, for the first time, a library of mutants in which every gene is disrupted. The hope is that phenotyping the mutants will reveal novel and interesting phenotypes that correlate with genes, to define the first functional map of a mammalian genome. This new milestone will have a great impact on our understanding of mammalian biology, and could significantly change the future of medical diagnosis and therapeutic development, where databases can be queried in silico for potential drug targets or underlying genetic causes of illnesses. Emerging innovative genetic strategies, such as somatic genetics, modifier screens and humanized mice, in combination with whole-genome mutagenesis will dramatically broaden the utility of the mouse. More significantly, allowing genome-wide genetic interrogations in the laboratory, will liberate the creativity of individual investigators and transform the mouse as a model for making original discoveries and establishing novel paradigms for understanding human biology and disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.