ArticleImmunology and cell biology2009
On the opposing views of the self-nonself discrimination by the immune system.
Article in Immunology and cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Self-tolerance curtails the B cell repertoire to microbial epitopes.JCI insight · 2019Trial
- The Effects of Alternate-Day Corticosteroids in Autoimmune Disease Patients.Autoimmune diseases · 2020Article
- Minding the gap: The impact of B-cell tolerance on the microbial antibody repertoire.Immunological reviews · 2019Review
- Learning from a contemporary history of immunology.Immunologic research · 2017Review
- Comment on: Ten experiments that would make a difference in understanding immune mechanisms.Cellular and molecular life sciences : CMLS · 2012Article
- The evolutionary context for a self-nonself discrimination.Cellular and molecular life sciences : CMLS · 2010Article
- The self/nonself issue: A confrontation between proteomes.Self/nonself · 2010Article
- Why Aire? Compensating for late bloomers.European journal of immunology · 2009Review
- On the critique by Colin Anderson of 'A reply to Dembic: on an end to the beginning of mis-understanding the immune response'.Scandinavian journal of immunology · 2009Article
- The discussion with Jacques Miller: illustrating the limitations of pure empiricism.Immunology and cell biologyArticle
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Abstract
Today's generally accepted view of the self-nonself discrimination was voiced by Miller(1) in 2004 in a thought-provoking essay. In spite of its popularity, this position has its limitations, which are analyzed here with a view toward establishing an interactive discussion that hopefully will culminate in agreed upon decisive experiments. The inadequacies of Miller's view of the self-nonself discrimination and their resolution under the associative recognition of antigen model are analyzed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.