ArticleInternational journal of obesity (2005)2009
Genetic subtype differences in neural circuitry of food motivation in Prader-Willi syndrome.
Article in International journal of obesity (2005), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Multidimensional Characterisation of Eating Behaviour in Genetic Obesity: A Systematic Review.Obesity facts · 2026Pooled it
- The Effects of Experimental Manipulation of Sleep Duration on Neural Response to Food Cues.Sleep · 2017Trial
- A reduced-energy intake, well-balanced diet improves weight control in children with Prader-Willi syndrome.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2013Trial
- The development and testing of the TTU food cue reactivity image bank.International journal of obesity (2005) · 2025Article
- Evaluation of Autonomic Nervous System Dysfunction in Childhood Obesity and Prader-Willi Syndrome.International journal of molecular sciences · 2023Article
- Prader-Willi Syndrome and Chromosome 15q11.2 BP1-BP2 Region: A Review.International journal of molecular sciences · 2023Review
- Progress in Brain Magnetic Resonance Imaging of Individuals with Prader-Willi Syndrome.Journal of clinical medicine · 2023Review
- Health Problems in Adults with Prader-Willi Syndrome of Different Genetic Subtypes: Cohort Study, Meta-Analysis and Review of the Literature.Journal of clinical medicine · 2022Article
- Recommendations for the diagnosis and management of childhood Prader-Willi syndrome in China.Orphanet journal of rare diseases · 2022Review
- Visual food cue processing in children with Prader-Willi Syndrome.Physiology & behavior · 2021Article
- Eye Tracking as a Marker of Hyperphagia in Prader-Willi Syndrome.Developmental neuropsychology · 2018Article
- Incidental memory for faces in children with different genetic subtypes of Prader-Willi syndrome.Social cognitive and affective neuroscience · 2017Article
- Puzzle Pieces: Neural Structure and Function in Prader-Willi Syndrome.Diseases (Basel, Switzerland) · 2015Review
- Obesity: pathophysiology and intervention.Nutrients · 2014 · on this mapReview
- Effects of metformin in children and adolescents with Prader-Willi syndrome and early-onset morbid obesity: a pilot study.Journal of pediatric endocrinology & metabolism : JPEM · 2014Article
- Evening hyperphagia and food motivation: a preliminary study of neural mechanisms.Eating behaviors · 2013Article
- Altered functional brain networks in Prader-Willi syndrome.NMR in biomedicine · 2013Article
- Social and emotional processing in Prader-Willi syndrome: genetic subtype differences.Journal of neurodevelopmental disorders · 2013Article
- Importance of reward and prefrontal circuitry in hunger and satiety: Prader-Willi syndrome vs simple obesity.International journal of obesity (2005) · 2012Article
- The neuroanatomy of genetic subtype differences in Prader-Willi syndrome.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2012Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundDifferences in behavioral phenotypes between the two most common subtypes of Prader-Willi syndrome (PWS) (chromosome 15q deletions and maternal uniparental disomy 15 (UPD) indicate that distinct neural networks may be affected. Though both subtypes display hyperphagia, the deletion subgroup shows reduced behavioral inhibition around food, whereas those with UPD are generally more able to maintain cognitive control over food intake impulses.
objectiveTo examine the neural basis of phenotypic differences to better understand relationships between genetic subtypes and behavioral outcomes. We predicted greater food motivation circuitry activity in the deletion subtype and greater activity in higher order cognitive regions in the UPD group, especially after eating. DESIGN AND
participantsNine individuals with PWS due to UPD and nine individuals with PWS due to (type 2) deletion, matched for age, gender and body mass index, underwent functional magnetic resonance imaging (fMRI) while viewing food images during two food motivation states: one before (pre-meal) and one after (post-meal) eating a standardized 500 kcal meal.
resultsBoth PWS subgroups showed greater activity in response to food pre- and post-meal compared with the healthy-weight group. Compared with UPD, the deletion subtype showed increased food motivation network activation both pre- and post-meal, especially in the medial prefrontal cortex (mPFC) and amygdala. In contrast, the UPD group showed greater activation than the deletion subtype post-meal in the dorsolateral prefrontal cortex (DLPFC) and parahippocampal gyrus (PHG).
conclusionThese preliminary findings are the first functional neuroimaging findings to support divergent neural mechanisms associated with behavioral phenotypes in genetic subtypes of PWS. Results are discussed within the framework of genetic mechanisms such as haploinsufficiency and gene dosage effects and their differential influence on deletion and UPD subtypes, respectively.
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