ArticleProceedings of the National Academy of Sciences of the United States of America2008
Membrane shape as a reporter for applied forces.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Single-cell topographical profiling of the immune synapse reveals a biomechanical signature of cytotoxicity.Science immunology · 2024Article
- Modelling membrane curvature generation using mechanics and machine learning.Journal of the Royal Society, Interface · 2022Article
- Value of models for membrane budding.Current opinion in cell biology · 2021Review
- The role of traction in membrane curvature generation.Molecular biology of the cell · 2018Article
- Catch Bonds at T Cell Interfaces: Impact of Surface Reorganization and Membrane Fluctuations.Biophysical journal · 2017Article
- Nanomechanical mechanism for lipid bilayer damage induced by carbon nanotubes confined in intracellular vesicles.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Trans-membrane area asymmetry controls the shape of cellular organelles.International journal of molecular sciences · 2015Article
- Membranes: Shaping biological matter.Nature materials · 2009Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent advances have enabled 3-dimensional reconstructions of biological structures in vivo, ranging in size and complexity from single proteins to multicellular structures. In particular, tomography and confocal microscopy have been exploited to capture detailed 3-dimensional conformations of membranes in cellular processes ranging from viral budding and organelle maintenance to phagocytosis. Despite the wealth of membrane structures available, there is as yet no generic, quantitative method for their interpretation. We propose that by modeling these observed biomembrane shapes as fluid lipid bilayers in mechanical equilibrium, the externally applied forces as well as the pressure, tension, and spontaneous curvature can be computed directly from the shape alone. To illustrate the potential power of this technique, we apply an axial force with optical tweezers to vesicles and explicitly demonstrate that the applied force is equal to the force computed from the membrane conformation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.