Trial reportArchives of general psychiatry2008
Depressive symptoms and change in abdominal obesity in older persons.
Trial report in Archives of general psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
94 citing papers in PubMed, 3 syntheses or guidelines pooled it, 197 citations in OpenAlex.
- Prevalence of depression and anxiety among children with type 1 and type 2 diabetes: a systematic review and meta-analysis.World journal of pediatrics : WJP · 2022Pooled it
- Pooled it
- Replication and reproducibility issues in the relationship between C-reactive protein and depression: A systematic review and focused meta-analysis.Brain, behavior, and immunity · 2018Pooled it
- BRIGHTEN Heart: Design and baseline characteristics of a randomized controlled trial for minority older adults with depression and cardiometabolic syndrome.Contemporary clinical trials · 2016Trial
- Daily stressors, past depression, and metabolic responses to high-fat meals: a novel path to obesity.Biological psychiatry · 2015Trial
- Marital discord, past depression, and metabolic responses to high-fat meals: Interpersonal pathways to obesity.Psychoneuroendocrinology · 2015Trial
- Effect of running therapy on depression (EFFORT-D). Design of a randomised controlled trial in adult patients [ISRCTN 1894].BMC public health · 2012Trial
- Obesity and onset of significant depressive symptoms: results from a prospective community-based cohort study of older men and women.The Journal of clinical psychiatry · 2010Trial
- Association between depression and metabolic dysfunction-associated steatotic liver disease: a cross-sectional analysis from the paracelsus 10,000 Study.Hepatology international · 2026Article
- Depression and MASLD: a shared burden of mind and metabolism.Hepatology international · 2026Article
- Body mass index mediates the relationship between depression and triglyceride levels: Evidence from a large national cohort.Journal of affective disorders · 2025Article
- Article
- Leptin's Inverse Association With Brain Morphology and Depressive Symptoms: A Discovery and Confirmatory Study Across 2 Independent Samples.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Antioxidant and Anti-Inflammatory Effects of Carotenoids in Mood Disorders: An Overview.Antioxidants (Basel, Switzerland) · 2023Review
- Incidence and Factors Associated with Hyperglycemia in Patients with First Hospitalization for Major Depression Disorder: A Large Cross-Sectional Sample.Neuropsychiatric disease and treatment · 2023Article
- Associations between depression and the incident risk of obesity in southwest China: A community population prospective cohort study.Frontiers in public health · 2023Article
- Clinical correlates and metabolic indicators of elevated fasting glucose in overweight/obese Chinese Han patients with first-episode and drug-naive major depressive disorder.Frontiers in endocrinology · 2023Article
- Weight changes and the incidence of depressive symptom in the middle-aged and older adults: findings from the Chinese nationwide cohort study.BMC public health · 2022Article
- Association between depressive symptoms and pericardial fat in healthy older men and women.Scientific reports · 2022Article
- Evidence and suggestions for establishing vitamin D intake standards in Koreans for the prevention of chronic diseases.Nutrition research and practice · 2022Review
34 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 8 institutions in 2 countries.
Funding
Abstract
contextDepression has been hypothesized to result in abdominal obesity through the accumulation of visceral fat. No large study has tested this hypothesis longitudinally.
objectiveTo examine whether depressive symptoms predict an increase in abdominal obesity in a large population-based sample of well-functioning older persons.
designThe Health, Aging, and Body Composition Study, an ongoing prospective cohort study with 5 years of follow-up.
settingCommunity-dwelling older persons residing in the areas surrounding Pittsburgh, Pennsylvania, and Memphis, Tennessee.
participantsA total of 2088 well-functioning white and black persons aged 70 to 79 years.
main outcome measuresBaseline depression was defined as a Center for Epidemiological Studies Depression score of 16 or higher. At baseline and after 5 years, overall obesity measures included body mass index (calculated as weight in kilograms divided by height in meters squared) and percentage of body fat (measured by dual-energy x-ray absorptiometry). Abdominal obesity measures included waist circumference, sagittal diameter, and visceral fat (measured by computed tomography).
resultsAfter adjustment for sociodemographics, lifestyle, diseases, and overall obesity, baseline depression was associated with a 5-year increase in sagittal diameter (beta = .054; P = .01) and visceral fat (beta = .080; P = .001).
conclusionsThis study shows that depressive symptoms result in an increase in abdominal obesity independent of overall obesity, suggesting that there may be specific pathophysiological mechanisms that link depression with visceral fat accumulation. These results might also help explain why depression increases the risk of diabetes and cardiovascular disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.