ArticleApplied and environmental microbiology2009
Regulation of carotenogenesis and secondary metabolism by nitrogen in wild-type Fusarium fujikuroi and carotenoid-overproducing mutants.
Article in Applied and environmental microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 62 citations in OpenAlex.
- Effects of functional characteristics of prickly ash leaves on yield following increased supply of nitrogen fertilizers.Frontiers in plant science · 2026Article
- Biosynthesis Regulation of Secondary Metabolite Production inJournal of fungi (Basel, Switzerland) · 2025Review
- Bioavailability and provitamin A activity of neurosporaxanthin in mice.Communications biology · 2023Article
- Production of Fungal Pigments: Molecular Processes and Their Applications.Journal of fungi (Basel, Switzerland) · 2022Review
- Relation between CarS expression and activation of carotenogenesis by stress inFrontiers in bioengineering and biotechnology · 2022Article
- GCN4 Regulates Secondary Metabolism through Activation of Antioxidant Gene Expression under Nitrogen Limitation Conditions in Ganoderma lucidum.Applied and environmental microbiology · 2021Article
- Neurosporaxanthin Overproduction byAntioxidants (Basel, Switzerland) · 2020Article
- Influence of the Nutrients on the Biomass and Pigment Production ofJournal of fungi (Basel, Switzerland) · 2019Article
- Comparative transcriptomic analysis unveils interactions between the regulatory CarS protein and light response in Fusarium.BMC genomics · 2019Article
- Conserved Responses in a War of Small Molecules between a Plant-Pathogenic Bacterium and Fungi.mBio · 2018Article
- Carotenoid Biosynthesis in Fusarium.Journal of fungi (Basel, Switzerland) · 2017Review
- Filamentous ascomycetes fungi as a source of natural pigments.Fungal biology and biotechnology · 2017Review
- Knock-down of the methyltransferase Kmt6 relieves H3K27me3 and results in induction of cryptic and otherwise silent secondary metabolite gene clusters in Fusarium fujikuroi.Environmental microbiology · 2016Article
- Article
- Nitrogen regulation of fungal secondary metabolism in fungi.Frontiers in microbiology · 2014Review
- Light-dependent functions of the Fusarium fujikuroi CryD DASH cryptochrome in development and secondary metabolism.Applied and environmental microbiology · 2013Article
- Functional analysis of the carS gene of Fusarium fujikuroi.Molecular genetics and genomics : MGG · 2013Article
- Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.PLoS pathogens · 2013Article
- Identification and regulation of fusA, the polyketide synthase gene responsible for fusarin production in Fusarium fujikuroi.Applied and environmental microbiology · 2012Article
- Adenylyl cyclase plays a regulatory role in development, stress resistance and secondary metabolism in Fusarium fujikuroi.PloS one · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fungus Fusarium fujikuroi (Gibberella fujikuroi MP-C) produces metabolites of biotechnological interest, such as gibberellins, bikaverins, and carotenoids. Gibberellin and bikaverin productions are induced upon nitrogen exhaustion, while carotenoid accumulation is stimulated by light. We evaluated the effect of nitrogen availability on carotenogenesis in comparison with bikaverin and gibberellin production in the wild type and in carotenoid-overproducing mutants (carS). Nitrogen starvation increased carotenoid accumulation in all strains tested. In carS strains, gibberellin and bikaverin biosynthesis patterns differed from those of the wild type and paralleled the expression of key genes for both pathways, coding for geranylgeranyl pyrophosphate (GGPP) and kaurene synthases for the former and a polyketide synthase for the latter. These results suggest regulatory connections between carotenoid biosynthesis and nitrogen-controlled biosynthetic pathways in this fungus. Expression of gene ggs1, which encodes a second GGPP synthase, was also derepressed in the carS mutants, suggesting the participation of Ggs1 in carotenoid biosynthesis. The carS mutations did not affect genes for earlier steps of the terpenoid pathway, such as fppS or hmgR. Light induced carotenoid biosynthesis in the wild type and carRA and carB levels in the wild-type and carS strains irrespective of nitrogen availability.
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