ArticleApplied and environmental microbiology2009
Metabolomic investigation of the bacterial response to a metal challenge.
Article in Applied and environmental microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 110 citations in OpenAlex.
- Statistical factorial design for optimum reduction of tellurite and production of tellurium nanostructure by a novel strain Phytobacter diazotrophicus Te1.Archives of microbiology · 2025Article
- Optimizing Anesthetic Practices for Mud Crab: A Comparative Study of Clove Oil, MS-222, Ethanol, and Magnesium Chloride.Antioxidants (Basel, Switzerland) · 2023Article
- The Klebsiella pneumoniaeInfection and immunity · 2023Article
- Decoding the metabolic response ofProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Do Volatiles Affect Bacteria and Plants in the Same Way? Growth and Biochemical Response of Non-Stressed and Cd-StressedAntioxidants (Basel, Switzerland) · 2022Article
- Effect of Sodium Selenite on the Metabolite Profile of Epichloë sp. Mycelia from Festuca sinensis in Solid Culture.Biological trace element research · 2022Article
- Tolerance, Adaptation, and Cell Response Elicited byInternational journal of molecular sciences · 2022Article
- A Novel Antibacterial Component and the Mechanisms of anInternational journal of molecular sciences · 2021Article
- A plasmid locus associated with Klebsiella clinical infections encodes a microbiome-dependent gut fitness factor.PLoS pathogens · 2021Article
- Untargeted Metabolomics Investigation on Selenite Reduction to Elemental Selenium byFrontiers in microbiology · 2021Article
- Metal-Resistance in Bacteria: Why Care?Genes · 2020Article
- The Uptake and Release of Amino Acids byFrontiers in microbiology · 2019Article
- Response of Gut Microbiota to Metabolite Changes Induced by Endurance Exercise.Frontiers in microbiology · 2018Article
- Identification of key proteins and pathways in cadmium tolerance of Lactobacillus plantarum strains by proteomic analysis.Scientific reports · 2017Article
- Metal-tolerant PAH-degrading bacteria: development of suitable test medium and effect of cadmium and its availability on PAH biodegradation.Environmental science and pollution research international · 2015Article
- Metabolomics reveals differences of metal toxicity in cultures of Pseudomonas pseudoalcaligenes KF707 grown on different carbon sources.Frontiers in microbiology · 2015Article
- Selenite Protection of Tellurite Toxicity Toward Escherichia coli.Frontiers in molecular biosciences · 2015Article
- Role of Tellurite Resistance Operon in Filamentous Growth of Yersinia pestis in Macrophages.PloS one · 2015Article
- Xanthan Gum Removal for 1H-NMR Analysis of the Intracellular Metabolome of the Bacteria Xanthomonas axonopodis pv. citri 306.Metabolites · 2014Article
- NMR-based metabolomic analysis of spatial variation in soft corals.Marine drugs · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pseudomonas pseudoalcaligenes KF707 is naturally resistant to the toxic metalloid tellurite, but the mechanisms of resistance are not known. In this study we report the isolation of a KF707 mutant (T5) with hyperresistance to tellurite. In order to characterize the bacterial response and the pathways leading to tolerance, we utilized Phenotype MicroArray technology (Biolog) and a metabolomic technique based on nuclear magnetic resonance spectroscopy. The physiological states of KF707 wild-type and T5 cells exposed to tellurite were also compared in terms of viability and reduced thiol content. Our analyses showed an extensive change in metabolism upon the addition of tellurite to KF707 cultures as well as different responses when the wild-type and T5 strains were compared. Even in the absence of tellurite, T5 cells displayed a "poised" physiological status, primed for tellurite exposure and characterized by altered intracellular levels of glutathione, branched-chain amino acids, and betaine, along with increased resistance to other toxic metals and metabolic inhibitors. We conclude that hyperresistance to tellurite in P. pseudoalcaligenes KF707 is correlated with the induction of the oxidative stress response, resistance to membrane perturbation, and reconfiguration of cellular metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.