ArticleThe Journal of physiology2009
The decrease in mature myostatin protein in male skeletal muscle is developmentally regulated by growth hormone.
Article in The Journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The trial behind it
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Trial
- A myostatin inhibitory antibody combined with insulin, partially rescues the musculoskeletal phenotype of female insulin-deficient diabetic mice.Frontiers in endocrinology · 2025Article
- Targeting Molecular Mechanisms of Obesity- and Type 2 Diabetes Mellitus-Induced Skeletal Muscle Atrophy with Nerve Growth Factor.International journal of molecular sciences · 2024Article
- Sex-specific increases in myostatin and SMAD3 contribute to obesity-related insulin resistance in human skeletal muscle and primary human myotubes.American journal of physiology. Endocrinology and metabolism · 2024Article
- Sex Differences in Inflammation and Muscle Wasting in Aging and Disease.International journal of molecular sciences · 2023Review
- Cord blood myostatin concentrations by gestational diabetes mellitus and fetal sex.Frontiers in endocrinology · 2023Article
- Association study between relative expression levels of eight genes and growth rate in Hungarian common carp (Saudi journal of biological sciences · 2022Article
- Myokines in Acromegaly: An Altered Irisin Profile.Frontiers in endocrinology · 2021Article
- Regulation of murine skeletal muscle growth by STAT5B is age- and sex-specific.Skeletal muscle · 2019Article
- Article
- Relative Contributions of Myostatin and the GH/IGF-1 Axis in Body Composition and Muscle Strength.Frontiers in physiology · 2018Article
- Myostatin and beyond in cirrhosis: all roads lead to sarcopenia.Journal of cachexia, sarcopenia and muscle · 2017Article
- Mice overexpressing growth hormone exhibit increased skeletal muscle myostatin and MuRF1 with attenuation of muscle mass.Skeletal muscle · 2017Article
- Age and sex differences in human skeletal muscle fibrosis markers and transforming growth factor-β signaling.European journal of applied physiology · 2017Article
- Insulin signaling and skeletal muscle atrophy and autophagy in transition dairy cows either overfed energy or fed a controlled energy diet prepartum.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Article
- Myostatin and the skeletal muscle atrophy and hypertrophy signaling pathways.Cellular and molecular life sciences : CMLS · 2014Review
- Longissimus dorsi transcriptome analysis of purebred and crossbred Iberian pigs differing in muscle characteristics.BMC genomics · 2014Article
- Identification and expression of a novel transcript of the growth and differentiation factor-11 gene.Molecular and cellular biochemistry · 2014Article
- Article
- Targeted loss of GHR signaling in mouse skeletal muscle protects against high-fat diet-induced metabolic deterioration.Diabetes · 2012Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myostatin inhibits myogenesis and there is reduced abundance of the mature protein in skeletal muscles of adult male compared with female mice. This reduction probably occurs after translation, which suggests that it is a regulated mechanism to reduce the availability of myostatin in males. Reduced myostatin may, thereby, contribute to the development of sexually dimorphic growth of skeletal muscle. Our first objective was to determine if the decrease in mature myostatin protein occurs before the linear growth phase to aid growth, or afterwards to maintain the mass of adult muscle. Mice were killed from 2 to 32 weeks and the gastrocnemius muscle was excised. Myostatin mRNA increased from 2 to 32 weeks and was higher in males than females (P < 0.001). In contrast, mature protein decreased in males after 6 weeks (P < 0.001). Our second objective was to determine if growth hormone (GH) induces the decrease in mature myostatin protein. GH increased myostatin mRNA and decreased the abundance of mature protein in hypophysectomised mice (P < 0.05). Our final objective was to determine if the decrease in mature protein occurs in skeletal muscles of male Stat5b(-/-) mice (Stat5b mediates the actions of GH). As expected, mature myostatin protein was not reduced in Stat5b(-/-) males compared with females. However, myostatin mRNA remained higher in males than females irrespective of genotype. These data suggest that: (1) the decrease in mature myostatin protein is developmentally regulated, (2) GH acting via Stat5b regulates the abundance of mature myostatin and (3) GH acts via a non-Stat5b pathway to regulate myostatin mRNA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.