Trial reportInternational journal of epidemiology2009
Role of breastfeeding cessation in mediating the relationship between maternal HIV disease stage and increased child mortality among HIV-exposed uninfected children.
Trial report in International journal of epidemiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00310726 (Short Duration Exclusive Breastfeeding With Abrupt Weaning to Reduce the Risk of Mother-to-Child HIV Transmission), which is not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Short Duration Exclusive Breastfeeding With Abrupt Weaning to Reduce the Risk of Mother-to-Child HIV Transmission
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Mortality risk and associated factors in HIV-exposed, uninfected children.Tropical medicine & international health : TM & IH · 2016Pooled it
- What do we know about children living with HIV-infected or AIDS-ill adults in Sub-Saharan Africa? A systematic review of the literature.AIDS care · 2016Pooled it
- Trial
- Child Growth According to Maternal and Child HIV Status in Zimbabwe.The Pediatric infectious disease journal · 2017Article
- Epidemiology of Acute Lower Respiratory Tract Infection in HIV-Exposed Uninfected Infants.Pediatrics · 2016Article
- Pattern of Infectious Morbidity in HIV-Exposed Uninfected Infants and Children.Frontiers in immunology · 2016Review
- Does the national program of prevention of mother to child transmission of HIV (PMTCT) reach its target in Ouagadougou, Burkina Faso?African health sciences · 2014Article
- Breastfeeding is associated with decreased pneumonia incidence among HIV-exposed, uninfected Kenyan infants.AIDS (London, England) · 2013Article
- Clonal amplification and maternal-infant transmission of nevirapine-resistant HIV-1 variants in breast milk following single-dose nevirapine prophylaxis.Retrovirology · 2013Article
- A simulation study of finite-sample properties of marginal structural Cox proportional hazards models.Statistics in medicine · 2012Article
- Time scale and adjusted survival curves for marginal structural cox models.American journal of epidemiology · 2010Article
- Task shifting routine inpatient pediatric HIV testing improves program outcomes in urban Malawi: a retrospective observational study.PloS one · 2010Article
- Use of antiretrovirals during pregnancy and breastfeeding in low-income and middle-income countries.Current opinion in HIV and AIDS · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundMaternal CD4 count predicts child mortality in HIV-uninfected children born to HIV-infected women.
methodsTo explore the mediating role of breastfeeding cessation in this relationship, we compared marginal structural models of maternal CD4 count on child death with and without adjustment for breastfeeding.
resultsIn crude analyses, children of mothers with CD4<200 during pregnancy were 3.2 times more likely to die by 18 months (CI 1.3-8.1) as children whose mothers had CD4>500. Earlier breastfeeding cessation was also associated with low CD4 (HR 1.8; CI 1.2-2.7). After adjusting for breastfeeding and low birth weight using a marginal structural model, the low CD4 count-child mortality association through 18 months was reduced 17%. The change was overestimated using a traditional Cox proportional hazards model (35% reduction in HR from 3.4 to 2.5).
conclusionsOur analysis suggests that only a small part of the effect of low vs high CD4 count on child mortality through 18 months is mediated through breastfeeding cessation. Our results must be taken into account when deciding whether or not to recommend breastfeeding for infants of HIV-infected mothers.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.