ArticleBMC genetics2008
Genomic complexity of the variable region-containing chitin-binding proteins in amphioxus.
Article in BMC genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Immunity: defense against infections essential for all living organisms.Frontiers in immunology · 2026Review
- Tethering of soluble immune effectors to mucin and chitin reflects a convergent and dynamic role in gut immunity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Recombinant SpTransformer proteins are functionally diverse for binding and phagocytosis by three subtypes of sea urchin phagocytes.Frontiers in immunology · 2024Article
- Environmental stress and nanoplastics' effects onFrontiers in immunology · 2023Article
- Secreted immunoglobulin domain effector molecules of invertebrates and management of gut microbial ecology.Immunogenetics · 2022Review
- Whole-Genome Resequencing of TwentyBioMed research international · 2020Article
- Individual Sea Urchin Coelomocytes Undergo Somatic Immune Gene Diversification.Frontiers in immunology · 2019Article
- Phagocytic intracellular digestion in amphioxus (Proceedings. Biological sciences · 2018Article
- Chitin protects the gut epithelial barrier in a protochordate model of DSS-induced colitis.Biology open · 2018Article
- SpTransformer proteins from the purple sea urchin opsonize bacteria, augment phagocytosis, and retard bacterial growth.PloS one · 2018Article
- Activity Augmentation of Amphioxus Peptidoglycan Recognition Protein BbtPGRP3 via Fusion with a Chitin Binding Domain.PloS one · 2015Article
- Article
- The amphioxus genome provides unique insight into the evolution of immunity.Briefings in functional genomics · 2012Review
- Macroevolutionary Immunology: A Role for Immunity in the Diversification of Animal life.Frontiers in immunology · 2012Article
- Innate immune complexity in the purple sea urchin: diversity of the sp185/333 system.Frontiers in immunology · 2012Article
- A role for variable region-containing chitin-binding proteins (VCBPs) in host gut-bacteria interactions.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- An Sp185/333 gene cluster from the purple sea urchin and putative microsatellite-mediated gene diversification.BMC genomics · 2010Article
- The basis for haplotype complexity in VCBPs, an immune-type receptor in amphioxus.Immunogenetics · 2010Article
- The origins of vertebrate adaptive immunity.Nature reviews. Immunology · 2010Review
- Hydractinia allodeterminant alr1 resides in an immunoglobulin superfamily-like gene complex.Current biology : CB · 2010Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundThe variable region-containing chitin-binding proteins (VCBPs) are found in protochordates and consist of two tandem immunoglobulin variable (V)-type domains and a chitin-binding domain. We previously have shown that these polymorphic genes, which primarily are expressed in the gut, exhibit characteristics of immune genes. In this report, we describe VCBP genomic organization and characterize adjacent and intervening genetic features which may influence both their polymorphism and complex transcriptional repertoire.
resultsVCBP genes 1, 2, 4, and 5 are encoded in a single contiguous gene-rich chromosomal region and VCBP3 is encoded in a separate locus. The VCBPs exhibit extensive haplotype variation, including copy number variation (CNV), indel polymorphism and a markedly elevated variation in repeat type and density. In at least one haplotype, inverted repeats occur more frequently than elsewhere in the genome. Multi-animal cDNA screening, as well as transcriptional profilingusing a novel transfection system, suggests that haplotype-specific transcriptional variants may contribute to VCBP genetic diversity.
conclusionThe availability of the Branchiostoma floridae genome (Joint Genome Institute, Brafl1), along with BAC and PAC screening and sequencing described here, reveal that the relatively limited number of VCBP genes present in the amphioxus genome exhibit exceptionally high haplotype variation. These VCBP haplotypes contribute a diverse pool of allelic variants, which includes gene copy number variation, pseudogenes, and other polymorphisms, while contributing secondary effects on gene transcription as well.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.